摘要
Multiple sclerosis(MS)is a complex chronic disease of the central nervous system(CNS)which includes three main anatomopathological characteristics:inflammation,demyelination,neurodegeneration.This pathology induces many clinical symptoms,depending on the site of the lesions,such as motor,sensitive,visual,urinary and cognitive manifestations.In addition,MS is a very heterogeneous disease that displays different clinical courses or phenotypes(relapsing/remitting MS,primary progressive MS(PPMS)and secondary progressive MS(SPMS).Both neurodegeneration and inflammation are present along the natural history of the disease.However,the balance of both phenomena varies according to the course of the disease.In relapsing/remitting MS form,the acute inflammation,mainly adaptive immunity,predominates over the neurodegeneration,being the main cause of the relapses.In SPMS and PPMS,the neurodegeneration predominates over the inflammation,which appears as chronic inflammation,being innate immunity(microglia and astroglia)the main feature in the neurodegenerative process.
基金
supported by the National Agency for Scientific and Technological Promotion(ANPCyT)
Argentina,PICT-2012-0656 grant(to CCF)
the RenéBaron Foundation and Institute of Translational Medicine and Biomedical Engineerie of the Italian Hospital(IMTIB,CONICET)(to CCF)
