摘要
皮肤是人体最大的器官,当其完整性遭到破坏时,创面愈合即启动。而人口老龄化、营养不良、应激反应、细菌感染、合并糖尿病等众多因素,影响着创面愈合,导致各种急性、慢性创面延迟愈合或者不愈合。目前,创面延迟愈合和不愈合是一个重大的医疗问题,亟须新的治疗方案。而雌激素补充治疗促进创面愈合的各个阶段已经得到了多方的证实。有大量的文章报道了雌激素补充治疗的有效性,但是争议仍然存在,特别是对雌激素受体及靶细胞的作用过程。新的分子技术增加了人们对雌激素对皮肤生物作用的理解,对发展雌激素补充治疗具有深远的意义。
Skin is the largest organ in the body,and when its integrity is damaged,wound healing is initiated.The aging of the population,malnutrition,stress response,bacterial infection,combined diabetes and other factors could affect wound healing,leading to various acute and chronic wound healing delayed or not healed.At present,delayed wound healing and nonhealing is still a major medical problem,and new treatment schemes are urgently needed.Estrogen supplementation therapy to promote wound healing the various stages have been proved by many studies.A large number of articles have reported the effectiveness of estrogen supplementation therapy,but controversy still exists,especially on the action process of estrogen receptor and target cells.New molecular techniques increased the understanding of the biological effects of estrogen on skin,and have far-reaching implications for the development of estrogen supplementation therapy.
作者
唐秋霞
余梦婷
简华刚
TANG Qiuxia;YU Mengting;JIAN Huagang(Emergency Surgery,the Second Affiliated Hospital Of Chongqing Medical University,Chongqing 400010,China)
出处
《重庆医学》
CAS
2020年第4期669-672,共4页
Chongqing medicine
关键词
雌激素
皮肤
受体
创面
愈合
estrogens
skin
receptors
wound surface
healing
