摘要
目的:探讨坤泰胶囊联合芳香化酶抑制剂来曲唑诱导排卵(OI)方案在多囊卵巢综合征(PCOS)不孕症治疗中的临床疗效,为激素替代疗法(HRT)寻找等效或替代药物。方法:选取2016年6月~2018年9月平煤神马医疗集团总医院妇科门诊就诊的已婚且有生育要求的PCOS不孕症患者100例,采用随机数字表法随机分为观察组(坤泰胶囊+来曲唑)和对照组(来曲唑),每组各50例。治疗周期为3个月,比较两组患者用药5天后雌二醇(E 2)水平、HCG日子宫内膜(Em)厚度、排卵率、宫颈黏液评分、超声下监测成熟卵泡个数、排卵率以及妊娠率。结果:①两组患者的年龄、BMI及病程相比较,差异无统计学意义(P>0.05)。②观察组的HCG日Em厚度及宫颈黏液评分显著高于对照组,用药5天后血清E 2水平显著低于对照组,差异有统计学意义(P<0.05)。③观察组成熟卵泡个数显著高于对照组,且治疗周期较对照组短,差异有统计学意义(P<0.05)。④观察组的排卵率及妊娠率显著高于对照组,差异有统计学意义(P<0.05)。结论:坤泰胶囊联合来曲唑OI方案能够有效改善PCOS不孕症患者的子宫内膜容受性,提高排卵率及妊娠率,临床上值得推广应用。
Objective:To explore the clinical efficacy of Kuntai capsule combined with aromatase inhibitor letrozole as ovulation inducer(OI)in the treatment of polycystic ovary syndrome(PCOS)infertility,and to find an equivalent or alternative drug for the previous hormone replacement therapy(HRT).Methods:From June 2016 to September 2018,100 married PCOS infertility patients with fertility requirements were included and randomly divided into observation group and control group with a random number table method,50 in each group.The treatment duration was 3 months,and the estradiol(E 2)level,endometrium(Em)thickness during HCG,ovulation rate,cervical mucus score,the number of mature folliclesand pregnancy rate were compared between the two groups after 5 days of treatment.Results:There was no significant difference in age,BMI and course of disease between the two groups(P<0.05).The thickness of Em and cervical mucus score in the observation group on HCG day were significantly higher than that in the control group.The serum E 2 level in observation group was significantly lower than that in the control group after 5d of treatment(P<0.05).The number of mature follicles in the observation group was significantly higher than that in the control group(P<0.05),but the treatment cycle was shorter than that in the control group(P<0.05).Ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Kuntai capsule combined with letrozole OI can effectively improve endometrial receptivity of patients with PCOS infertility,improve ovulation rate and pregnancy rate,which deserves further clinical application.
作者
李幸丽
LI Xing-li(Department of Gynaecology,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 450003,China)
出处
《中国合理用药探索》
CAS
2020年第2期58-62,共5页
Chinese Journal of Rational Drug Use
关键词
坤泰胶囊
芳香化酶抑制剂
来曲唑
多囊卵巢综合征
不孕症
诱导排卵
Kuntai capsule
aromatase inhibitors
letrozole
polycystic ovary syndrome
infertility
ovulation induction
