摘要
目的探讨涎液化糖链抗原(KL-6)与1型辅助性T细胞/2型辅助性T细胞(Th1/Th2)细胞因子在结缔组织病相关性间质性肺炎(CTD-IP)中的表达及临床意义。方法选择2017.01至2019.01间收治的77例CTD-IP患者纳为CTD-IP组,60例无肺间质病变CTD者纳为CTD组,50例健康体检合格者为健康组,比较三组血清涎液化糖链抗原(KL-6)、Th1细胞因子γ干扰素(IFN-γ)、Th2细胞因子白介素-4(IL-4)及Th1/Th2(IFN-γ/IL-4)水平,并根据CTD-IP患者肺通气障碍、肺弥散功能障碍严重程度及影像学表现,对CTD-IP组患者进行分组,统计CTD-IP患者血清KL-6、IFN-γ、IL-4及IFN-γ/IL-4表达水平,并分析以上血清物质在评估CTD-IP患者病情中的效果。结果健康对照组、CTD组及CTD-IP组中,血清KL-6及IL-4水平呈依次上升趋势,IFN-γ及IFN-γ/IL-4水平呈依次下降趋势,组间差异均显著(P<0.05);CTD-IP患者肺通气轻度障碍组、中度障碍组及重度障碍组中,血清KL-6及IL-4水平呈依次上升趋势,IFN-γ及IFN-γ/IL-4水平呈依次下降趋势,组间差异均显著(P<0.05);CTD-IP患者肺弥散轻度障碍组、中度障碍组及重度障碍组中,血清KL-6及IL-4水平呈依次上升趋势,IFN-γ及IFN-γ/IL-4水平呈依次下降趋势,组间差异均显著(P<0.05);CTD-IP患者HRCT表现活动性组血清KL-6、IFN-γ、IFN-γ/IL-4水平明显高于非活动性组(P<0.05),IL-4水平显著低于非活动性组(P<0.05)。结论血清KL-6、IFN-γ、IL-6及IFN-γ/IL-6水平在反映CTD-IP患者肺通气功能障碍、肺弥散功能障碍、疾病活动期中具有良好应用价值,可作为反映CTD-IP患者病情的可靠血清参考物质。
Objective To investigate the expression and clinical significance of Krebs von den Lungen-6(KL-6)and T helper 1/T helper 2(Th1/Th2)cytokines in the connective tissue disease-associated interstitial pneumonia(CTD-IP).Methods A total of 77 CTD-IP patients(CTD-IP group),60 CTD patients(CTD group),and 50 healthy volunteers(healthy group)examined in our hospital from January 2017 to January 2019 were enrolled for this study.The CTD-IP group was further divided into several subgroups according to the severity of pulmonary ventilation disorder,pulmonary diffuse dysfunction,and the imaging findings of high resolution CT(HRCT).The serum KL-6,Th1 cytokine interferon-γ(IFN-γ),Th2 cytokine interleukin-4(IL-4)and Th1/Th2(IFN-γ/IL-4)levels were compared within the groups and subgroups(P<0.05).Then the values of the above-mentioned serum indicators in assessing the condition of CTD-IP patients were also analyzed.Results In the healthy control group,CTD group and CTD-IP group,serum KL-6 and IL-4 levels had an increasing trend,meanwhile,the IFN-γand IFN-γ/IL-4 levels had a decreasing trend,with statistical significant differences between two groups(P<0.05).In the mild,moderate,and severe pulmonary ventilation disorder subgroups,the serum KL-6 and IL-4 levels had an increasing trend,meanwhile,the IFN-γand IFN-γ/IL-4 levels had a decreasing trend,with statistical significant differences between two subgroups(P<0.05).In the mild,moderate,and severe pulmonary diffuse dysfunction subgroups,the serum KL-6 and IL-4 levels had an increasing trend,meanwhile,the IFN-γand IFN-γ/IL-4 levels had a decreasing trend,with statistical significant differences between two subgroups(P<0.05).In the subgroups with different HRCT imaging findings,serum KL-6,IFN-γ,IFN-γ/IL-4 levels were significantly higher in the active group than the inactive group(P<0.05),and IL-4 levels were significantly lower in the active group than the inactive group(P<0.05).Conclusion Serum KL-6,IFN-γ,IL-6 and IFN-γ/IL-6 levels have a good application value in refl
作者
岳欢欢
黎联
Yue Huanhuan;Li Lian(Department of Respiratory Medicine,Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China;Department of Respiratory Medicine,Jiangjin Centre Hospital,Chongqing 402260,China)
出处
《中华肺部疾病杂志（电子版）》
CAS
2020年第1期18-22,共5页
Chinese Journal of Lung Diseases(Electronic Edition)
基金
国家自然科学基金资助项目(81200729)
