摘要
目的探讨大学生抑郁症患者视觉信息的前注意加工功能,为抑郁症的诊断提供理论依据。方法采用偏差刺激呈现频率为20%的偏差-标准刺激反转的oddball范式,对17例大学生抑郁症患者和17例健康大学生的视觉失匹配负波(mismatch negativity,MMN)进行比较,使用重复测量方差分析方法进行数据分析。结果大学生抑郁症患者的150 ms视觉MMN波幅[(-0.213±1.672)μV]小于健康大学生的150 ms视觉MMN波幅[(-1.774±1.174)μV,F=11.141,P=0.002],差异具有统计学意义(P<0.05)。大学生抑郁症患者50 ms MMN的平均波幅[(-0.673±1.520)μV]与健康大学生没有差异[(-0.998±1.058)μV,F=0.557,P=0.461]。结论大学生抑郁症患者视觉信息前注意加工存在障碍。
Objective To explore pre-attentive information processing in MDD undergraduate students indexed by visual mismatch negativity(MMN) and provide scientific theory basis for the diagnosis of MDD. Methods The deviant-standard reverse oddball paradigm was used to obtain the duration visual MMN in 17 MDD students and 17 gender-/age-healthy undergraduate students. All data were analyzed by statistics means of repeated measurement of F test. Results The amplitudes of 150 ms MMN were smaller in MDD undergraduate students((-0.213±1.672)μV) than healthy undergraduate students((-1.774±1.174)μV, F=11.141, P=0.002), whereas the 50 ms MMN did not differ between MDD students((-0.673±1.520)μV) and healthy undergraduate((-0.998±1.058)μV, F=0.557, P=0.461). Conclusion Pre-attentive visual information processing is impaired in MDD undergraduate students.
作者
乔正学
孙国栋
赵晓云
王帅
邱晓惠
杨秀贤
杨艳杰
QIAO Zheng-xue;SUN Guo-dong;ZHAO Xiao-yun;WANG Shuai;QIU Xiao-hui;YANG Xiu-xian;YANG Yan-jie(Department of Medical Psychology,Public Health College of Harbin Medical University,Harbin 150081,China;Planning Division,Harbin Medical University,Harbin 150081,China)
出处
《哈尔滨医科大学学报》
CAS
2019年第4期442-445,共4页
Journal of Harbin Medical University
基金
黑龙江省博士后基金(LBH-Z16151)
关键词
抑郁症
大学生
前注意加工
视觉失匹配负波
major depressive disorder
undergraduate students
pre-attentive processing
visual mismatch negativity
