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智能化纳米释药系统用于细菌感染治疗的研究进展 被引量:4

Progress on intelligent nano-drug release system for treating bacterial infection
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摘要 细菌耐药性的相关研究已成为多学科交叉研究的热点,纳米技术因其独特的物化性质在药物递送系统(drug delivery systems,DDSs)的应用中具有可以改善药物的药代动力学和药效学特性,为应对全球细菌抗生素耐药性问题提供了一种新的策略。作为药物载体,理想的纳米粒子必须具有较高的载药量,将药物运送到特定的病理部位和(或)靶细胞,同时不发生药物泄漏,并且在作用部位迅速释放药物。为此,人们积极寻求各种“智能”纳米释药系统,这种纳米释药系统可以对内部或外部刺激(如pH、氧化还原、温度、磁和光等)进行响应,从而实现对药物的可控释放。本文围绕pH、温度、光照以及酶和其他内源或外源因子刺激响应的智能化抗菌药物递送系统领域的最新研究进展进行了评述。 Bacterial drug resistance has become the focus of interdisciplinary studies.Nanotechnology can improve the pharmacokinetics of drugs in the application of drug delivery system(drug delivery systems,DDSs)because of its unique physical and chemical properties,which provides a new strategy to deal with the global bacterial resistance.As a drug carrier,the ideal nanoparticles must have a high drug loading,transport the drug to a specific pathological site and/or target cells,do not leak the drug,and release the drug quickly at the site of action.Therefore,people actively seek a variety of“intelligent”nano-drug release systems,which can respond to internal or external stimuli to achieve controllable drug release including pH,redox,temperature,magnetism and light.In this paper,the advances in the field of intelligent antibacterial drug delivery stimulated by pH,temperature,light and enzyme and other intrinsic or exogenous factors are reviewed.
作者 宋智勇 吴阳 韩鹤友 SONG Zhiyong;WU Yang;HAN Heyou(College of Science,Huazhong Agricultural University,Wuhan 430070,China;State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China;College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070,China)
出处 《华中农业大学学报》 CAS CSCD 北大核心 2020年第1期1-9,共9页 Journal of Huazhong Agricultural University
基金 国家自然科学基金项目(21807036 21778020) 广西科技重大专项(桂科AA18118046)
关键词 药物递送系统 智能化 纳米载体 耐药性细菌 超级细菌 多药耐药 抗生素 药物载体 精准释放 光响应 drug delivery systems intelligent nanocarrier multidrug resistance bacteria super bacteria multidrug resistance antibiotics drug carrier precise release light responsive
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