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Bmi-1及E-钙黏蛋白在宫颈鳞状细胞癌中的表达及意义 被引量:3

The expression and significance of Bmi-1 and E-cadherin in cervical squamous cell carcinoma
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摘要 目的探讨Bmi-1和E-钙黏蛋白(E-cadherin)在宫颈鳞状细胞癌中的表达及意义。方法用免疫组化SP法检测Bmi-1和E-cadherin在138例宫颈鳞状细胞癌组织、60例正常宫颈组织中的表达情况,分析宫颈鳞状细胞癌组织中Bmi-1、E-cadherin表达与临床特征的关系及二者的相关性,采用Kaplan-Meier绘制生存曲线,采用多因素Cox回归分析探讨宫颈鳞状细胞癌患者预后的影响因素。结果宫颈鳞状细胞癌组织中Bmi-1阳性表达率明显高于正常宫颈组织,E-cadherin阳性表达率明显低于正常宫颈组织,差异均有统计学意义(P﹤0.01)。低分化、临床分期为Ⅱ期、浸润深度﹥1/2、有淋巴结转移的宫颈鳞状细胞癌患者的宫颈鳞状细胞癌组织中Bmi-1阳性表达率均高于高中分化、临床分期为Ⅰ期、浸润深度≤1/2、无淋巴结转移患者,E-cadherin阳性表达率均低于高中分化、临床分期为Ⅰ期、浸润深度≤1/2、无淋巴结转移患者,差异均有统计学意义(P﹤0.05)。宫颈鳞状细胞癌组织中Bmi-1与E-cadherin的表达呈负相关(P﹤0.01)。Bmi-1阳性表达患者中位生存时间明显短于阴性表达患者,E-cadherin阳性表达患者中位生存时间明显长于阴性表达患者,差异均有统计学意义(P﹤0.01)。低分化、临床分期为Ⅱ期、有淋巴结转移、Bmi-1阳性表达和E-cadherin阴性表达均为宫颈鳞状细胞癌患者预后的独立危险因素(P﹤0.05)。结论Bmi-1可能通过抑制E-cadherin的表达诱导上皮-间充质转化(EMT),从而促进宫颈癌细胞的侵袭和转移。 Objective To explore the expression of Bmi-1 and epithelia cadherin(E-cadherin)protein in cervical squamous cell carcinoma and their significance.Method Immunohistological streptavidin-peroxidase-biotin(SP)assay was utilized to determine the expression of Bmi-1 and E-cadherin in 138 cases with cervical squamous cell carcinoma and in 60 cases with normal cervix,the relationship between Bmi-1 and E-cadherin expression in cervical squamous cell carcinoma and the association with clinical characteristics were analyzed,Kaplan-Meier survival analysis was performed,and multivariate Cox regression analysis was conducted to investigate the factors influencing the prognosis of patients with cervical squamous cell carcinoma.Result The positive expression of Bmi-1 in cervical squamous cell carcinoma tissues was higher than that in normal cervix,while E-cadherin expression was lower instead,indicating statistically significant differences(P<0.01).The positive expression of Bmi-1 were significantly higher in cervical squamous cell carcinoma tissues with lower degree of differentiation,clinical stage II,depth of invasion>1/2,and positive lymph node metastasis compared to those with moderate to high-middle differentiation,clinical stage I,depth of invasion≤1/2,and negative lymph node metastasis,while E-cadherin expression were lower instead,showing notable differences(P<0.05).Bmi-1 and E-cadherin expression in the cervical squamous cell carcinoma were negatively correlated with each other(P<0.01).Positive Bmi-1 expression was evidently associated with shorter survival time compared to those with negative expression of Bmi-1,inversely,patients with positive E-cadherin expression demonstrated longer survival time than those with negative expression,and the differences were of statistical significance(P<0.01).Multivariate Cox regression analysis showed that,lower differentiation,clinical stage II,presence of lymph node metastasis,positive Bmi-1 expression and negative E-cadherin expression were independent prognostic factors for
作者 赵莉莉 杨筱青 ZHAO Lili;YANG Xiaoqing(Department of Gynecology and Obstetrics,Women&Infants Hospital of Zhengzhou,Zhengzhou 450012,He’nan,China)
出处 《癌症进展》 2020年第2期164-167,共4页 Oncology Progress
关键词 宫颈鳞状细胞癌 BMI-1 E-钙黏蛋白 预后 上皮-间充质转化 cervical squamous cell carcinoma Bmi-1 E-cadherin prognosis epithelial-mesenchymal transition
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