摘要
目的探讨老年急性前壁心肌梗死患者心脏瓣膜钙化与冠状动脉病变的关系。方法采用回顾性研究方法,选取2007年1月至2017年12月首都医科大学附属北京友谊医院收治的行急诊冠脉造影的急性前壁心肌梗死的老年患者453例,分析其心脏瓣膜钙化情况,根据是否存在心脏瓣膜钙化分为钙化组和无钙化组,比较两组患者的一般资料和基础疾病、实验室指标、冠脉病变程度,分析心脏瓣膜钙化的相关影响因素。结果心脏瓣膜钙化组的年龄(71岁vs.66岁)、女性比率(49.43%vs.40.79%)、入院收缩压、空腹血糖水平、高敏感C反应蛋白(hs-CRP)水平(7.13±9.03 mg/L vs.5.56±7.86 mg/L)、氨基末端脑钠肽前体(NT-proBNP)水平(1375.47±3682.90 ng/dl vs.642.99±1126.98 ng/dl)明显高于无心脏瓣膜钙化组。心脏瓣膜钙化组的冠脉完全闭塞比率(23.86%vs.15.88%)、三支血管或左主干病变比率(54.55%vs.41.88%)明显高于无心脏瓣膜钙化组。Logistic回归分析显示,年龄、入院收缩压水平、空腹血糖水平、冠脉完全闭塞比例、三支血管或左主干病变与心脏瓣膜钙化独立相关。结论对于老年急性前壁心肌梗死患者,心脏瓣膜钙化与冠脉病变程度独立相关,与冠心病的部分危险因素也相关。
Objective To explore the relationship between cardiac valve calcification and coronary artery lesions in elderly patients with acute anterior wall myocardial infarction.Methods 453 elderly patients with acute anterior wall myocardial infarction who underwent emergency coronary angiography in our hospital from Jan 2007 to Dec 2017 were retrospectively selected.The patients were divided into the calcification group and the non-calcification group according to the presence or absence of heart valve calcification.The patients’ general information,basic diseases,laboratory examination results and the severity of coronary artery lesions were compared between the two groups,and the related factors of heart valve calcification were analyzed.Results The age(71 vs.66),female proportion(49.43% vs.40.79%),systolic blood pressure at admission,fasting blood glucose,hs-CRP(7.13±9.03 mg/L vs.5.56±7.86 mg/L) and NT-proBNP levels(1 375.47±3 682.90 ng/dl vs.642.99±1 126.98 ng/dl) in the heart valve calcification group were significantly higher than those in the non-heart valve calcification group.The proportion of complete occlusion of coronary artery and three vessels or left main coronary artery lesions in the cardiac valve calcification group was significantly higher than those in the non-heart valve calcification group.Logistic regression analysis showed that age,systolic blood pressure at admission,fasting blood glucose level,proportion of complete coronary occlusion,three vessels or left main coronary artery lesions were independently associated with cardiac valve calcification.Conclusion For elderly patients with acute anterior wall myocardial infarction,heart valve calcification is independently related to the severity of coronary artery disease and some risk factors of coronary artery disease.
作者
王宇朋
李虹伟
王萍
陈晖
WANG Yu-peng;LI Hong-wei;WANG Ping(Department of Geriatrics,Capital Medical University,Beijing 100050,China;Cardiovascular Center Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《临床和实验医学杂志》
2020年第3期275-278,共4页
Journal of Clinical and Experimental Medicine
基金
首都医学科研专项发展基金(编号:2014-3-2024)
关键词
老年人
急性前壁心肌梗死
瓣膜钙化
冠状动脉病变
Elderly
Acute myocardial infarction
Valve calcification
Coronary artery lesions
