摘要
Knops血型系统是国际输血协会(ISBT)1992年确认的独立的血型系统,命名KN,数字命名022,由9个抗原组成。红细胞Kn抗原在1970年首次被报道,其基因产物为KN抗原糖蛋白,即补体Ⅰ型受体(CR1,CD35),CR1主要作用为参与抑制补体激活,是重要的红细胞免疫机制参与者,且其表达数量的多态性与系统性红斑狼疮(SLE)、疟疾等多种疾病密切相关。Knops系统抗体一般不结合补体,不引起溶血反应,但在一些孕妇血清中可以检测到抗Knops抗体,一般只是直接抗人球蛋白试验(DAT)阳性,多数不引起新生儿溶血性疾病(HDN)。本文主要对Knops血型系统研究进展作一综述。
The Knops blood group system is an independent blood group system identified by International Society of Blood Transfusion(ISBT)in 1992.It is named KN and 022 digitally.It consists of 9 antigens.The antigens of Erythrocyte Kn were first reported in 1970,and their gene product is Kn antigen glycoprotein,as complement Ⅰ receptor(CR1,CD35).CR1,as an important participant of the immune mechanism on erythrocytes,plays a major role on inhibiting complement activation and the polymorphism of its expressed quantity is closely related to systemic lupus erythematosus(SLE),malaria and other diseases.Knops system antibodies generally do not bind complement and do not cause hemolytic reaction.However,anti-knops antibodies can be detected in the serum of some pregnant women.Generally,they are only directly anti-human globulin test(DAT)positive,and most of them do not cause neonatal hemolytic diseases(HDN).This paper mainly reviews the research progress of Knops blood type system.
作者
任凯
田稳
李凌波
REN Kai;TIAN Wen;LI Ling-Bo(School of Basic Medical Science of Jilin University,Changchun 130021,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2020年第4期504-508,F0004,共6页
Chinese Journal of Immunology
基金
吉林省科技厅科技发展计划资助项目(20180311063YY,20160204016SF)
