摘要
人类肠道微生物已越来越受到医学界的广泛关注,人类肠道微生物不仅在人类健康方面,而且在人类疾病的发生和发展方面都有很大的作用。人们不断发现微生物与癌症之间的联系,特别是肠道微生物群和肠道肿瘤之间的联系。宏基因组学作为微生物研究的一种重要研究方法,在微生物与结直肠癌研究中发挥越来越重要的作用。近年来,通过宏基因组学研究肠道微生物菌群的变化为结直肠癌的发生和发展提供了新的见解,并且强调了癌症微生物群中宿主-微生物和微生物间相互作用的重要性。本综述回顾了通过宏基因组学研究肠道微生物与结直肠癌之间的关系,希望为癌症预防、诊断和治疗提供新的机会。
Human gut microbes have received increasing attention in the medical community,and they have a great role not only in human health,but also in the occurrence and development of human diseases.The link between microbes and cancer,especially between the gut microbiota and intestinal tumors,is constantly being discovered.Metagenomics,as an important research method in microbial research,plays an increasingly important role in the study of microbial and colorectal cancer.In recent years,the study of gut microbiota by metagenomics has provided new insights into the development and progression of colorectal cancer,which emphasize the importance of host-microbe and microbial interactions in cancer microbiota.This article reviews the relationship between gut microbiota and colorectal cancer through metagenomics,and is expected to open up new opportunities for prevention,diagnosis and treatment of cancer.
作者
李智杰
赵琦
吴华星
LI Zhijie;ZHAO Qi;WU Huaxing(Endoscopy Room,Harbin Medical University Cancer Hospital,Harbin 150081,China)
出处
《实用肿瘤学杂志》
CAS
2020年第1期93-96,共4页
Practical Oncology Journal
关键词
肠道微生物
结直肠癌
宏基因组学
Intestinal microbes
Colorectal cancer
Metagenomics
