摘要
目的:探讨血清25羟维生素D[25(OH)D]水平与妊娠期甲状腺功能状态的相关性。方法:选择2017年6月至2018年4月收治的80例亚临床甲状腺功能减退症(SCH)患者为SCH组,另选择同期健康孕妇70例为对照组,在孕24~28周检测血清25(OH)D、甲状腺过氧化物酶抗体(TPOAb)、游离三碘甲状腺原氨酸(FT3)、促甲状腺激素(TSH)、游离甲状腺素(FT4)水平,分析25(OH)D与甲状腺功能指标的关系。结果:SCH组孕妇血清TSH水平及TPOAb阳性率均显著高于对照组(P<0.05),SCH组孕妇血清FT3、25(OH)D水平显著低于对照组(P<0.05),两组孕妇血清FT4水平无显著差异(P>0.05);SCH组孕妇维生素D缺乏率显著高于对照组(P<0.05);缺乏组孕妇血清TSH、FT3水平和TPOAb阳性率均显著高于不缺乏组(P<0.05),两组孕妇血清FT4水平无显著差异(P>0.05);25(OH)D与TSH、TPOAb水平呈负相关(P<0.05),25(OH)D与FT3水平呈正相关(P<0.05)。结论:妊娠中晚期妇女维生素D缺乏与SCH密切相关,维生素D缺乏、TPOAb阳性可能是妊娠期妇女并发SCH的重要因素。
Objective:To explore the correlation between serum 25-hydroxyvitamin D[25(OH)D]level and thyroid function status during pregnancy.Methods:80 patients with subclinical hypothyroidism(SCH)admitted between June 2017 to April 2018 were enrolled in SCH group.Another 70 healthy pregnant women were selected as control group.The levels of serum 25(OH)D,thyroid peroxidase antibody(TPOAb)free triiodothyronine(FT3),thyroid stimulating hormone(TSH)and free thyroxine(FT4)were detected at 24 to 28 weeks of gestation,and the relationship between 25(OH)D and thyroid function indexes was analyzed.Results:The level of serum TSH and positive rate of TPOAb in SCH group were significantly higher than those in control group(P<0.05)while the levels of serum FT3 and 25(OH)D in SCH group were significantly lower than that in control group(P<0.05),and there was no significant difference in FT4 level between the two groups(P>0.05).The vitamin D deficiency rate in SCH group was significantly higher than that in control group(P<0.05).The levels of serum TSH and FT3 and positive rate of TPOAb in deficiency group were significantly higher than those in insufficiency group(P<0.05),and there was no significant difference in the serum FT4 level between the two groups(P>0.05).25(OH)D was negatively correlated with the levels of TSH and TPOAb(P<0.05),and 25(OH)D was positively correlated with FT3 level(P<0.05).Conclusion:Vitamin D deficiency in women with advanced pregnancy is closely related to SCH.Vitamin D deficiency and TPOAb positive may be important factors for SCH in women during pregnancy.
作者
肖敏
苏燕
孙春萍
XIAO Min;SU Yan;SUN Chunping(The First People's Hospital of Hefei, Anhui Hefei 230061, China)
出处
《河北医学》
CAS
2020年第2期282-286,共5页
Hebei Medicine
基金
安徽省自然科学基金项目，(编号:2007063112)
