摘要
目的:探讨低剂量与高剂量枸橼酸咖啡因对原发性呼吸暂停早产儿呼吸暂停次数、相关不良反应事件和临床结局的影响。方法:研究对象选取我院2017年1月到2018年12月收治的128例原发性呼吸暂停患儿,采用前瞻性随机数字表法分为两组,每组各64例患儿。对照组患儿采用低剂量枸橼酸咖啡因治疗,观察组患儿采用高剂量枸橼酸咖啡因治疗,比较两组患儿的治疗效果、不良反应事件发生情况和临床结局。结果:观察组的呼吸暂停次数明显少于对照组,撤机成功率和治疗有效率明显高于对照组,差异均具有统计学意义(均P<0.05)。两组的给氧治疗天数和机械通气天数相比,差异均无统计学意义(均P>0.05)。两组患儿的不良反应事件比较,差异无统计学意义(P>0.05)。两组患儿的临床结局比较,差异无统计学意义(P>0.05)。结论:枸橼酸咖啡因的首剂量为20ms/kg,每日维持剂量为15ms/kg时,治疗早产儿原发性呼吸暂停疗效显著。
Objective:To investigate the effects of low-dose and high-dose caffeine citrate on apnea frequency, related adverse reactions and clinical outcomes in premature infants with primary apnea. Methods: 128 children with primary apnea admitted to our hospital from January 2017 to December 2018 were randomly divided into two groups, 64 in each group. The control group was treated with low-dose caffeine citrate, while the observation group was treated with high-dose caffeine citrate. The therapeutic effects, adverse events and clinical outcomes of the two groups were compared. Result: The number of apnea in the observation group was significantly less than that in the control group, and the success rate of weaning and the effective rate of treatment were significantly higher than those in the control group, the difference was statistically significant (all P<0.05). There was no significant difference in the days of oxygen therapy and mechanical ventilation between the two groups (all P>0.05). There was no significant difference in adverse reaction events between the two groups (P>0.05). There was no significant difference in the days of oxygen therapy and mechanical ventilation between the two groups (all P>0.05). There was no significant difference in adverse reaction events between the two groups (P>0.05). There was no significant difference in clinical outcomes between the two groups (P>0.05). Conclusion: When the initial dose of caffeine citrate is 20 ms/kg and the daily maintenance dose is 15 ms/kg, the therapeutic effect of caffeine citrate on primary apnea of premature infants is remarkable.
作者
刘志华
史莉莉
岳金超
魏朝霞
张丙金
焦海妹
LIU Zhihua;SHI Lili(Shengli Oilfield Central Hospital, Shandong Dongying 257000, China)
出处
《河北医学》
CAS
2020年第2期215-218,共4页
Hebei Medicine
基金
山东省自然科学基金资助项目，(编号ZF2017SP029)
