摘要
目的研究金水宝胶囊联合硫酸特布他林吸入粉雾剂治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法选取2015年12月-2017年12月新疆维吾尔自治区人民医院接收的100例慢性阻塞性肺疾病急性加重期患者为研究对象,随机分为对照组和治疗组,每组各50例。对照组雾化给予硫酸特布他林吸入粉雾剂,250μg/次,1次/6 h。治疗组在对照组基础上口服金水宝胶囊,3粒/次,3次/d。5d为1个疗程,两组患者持续治疗2个疗程。观察两组患者临床疗效,同时比较治疗前后两组肺功能指标、血气分析指标。结果治疗后,对照组和治疗组的总有效率分别为82.00%和96.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者1秒钟用力呼气量(FEV1)、FEV1占预计值的百分比(FEV1%Pred)和FEV1/用力肺活量(FVC)水平均显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组肺功能指标水平显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者pH值、动脉氧分压(p O2)均显著升高,二氧化碳分压(p CO2)水平显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组血气分析指标改善程度显著高于对照组,两组比较差异具有统计学意义(P<0.05)。结论金水宝胶囊联合硫酸特布他林吸入粉雾剂治疗慢性阻塞性肺疾病急性加重期具有较好的临床疗效,能够改善肺功能和血气指标,安全性较高,值得临床推广。
Objective To study the clinical effect of Jinshuibao Capsules combined with Terbutaline Sulphate Powder for inhalation in treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods Patients(100 cases) with acute exacerbation of chronic obstructive pulmonary disease in People’s Hospital of Xinjiang Uygur Autonomous Region from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were atomization inhalation administered with Terbutaline Sulphate Powder for inhalation, 250 μg/time, once every 6 h. Patients in the treatment group were po administered with Jinshuibao Capsules on the basis of the control group, 3 grains/time, three times daily. A course had 5 d, and patients in two groups were treated for 2 courses of treatment. After treatment, the clinical efficacies were evaluated, and lung function indexes and blood gas indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 96.00%, respectively, and there was difference between two groups(P < 0.05). After treatment, the levels of FEV1, FEV1% Pred, and FEV1/FVC in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the lung function indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of pH value and p O2 in two groups were significantly increased, but the levels of p CO2 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the blood gas indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Jinshuibao Capsules combined with Terbutaline Sulphate Powder for inhalation has clinic
作者
汪海涛
吴长东
凌敏
WANG Hai-tao;WU Chang-dong;LING Min(Second Department of Respiratory Medicine,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Department of Critical Care Medicine,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)
出处
《现代药物与临床》
CAS
2019年第12期3594-3597,共4页
Drugs & Clinic
关键词
金水宝胶囊
硫酸特布他林吸入粉雾剂
慢性阻塞性肺疾病急性加重期
肺功能指标
血气分析指标
Jinshuibao Capsules
Terbutaline Sulphate Powder for inhalation
acute exacerbation of chronic obstructive pulmonary disease
lung function index
blood gas index
