摘要
目的:探讨低分子肝素(LMWH)联合华法林治疗开胸术后急性肺栓塞(APE)的临床疗效。方法:选取90例开胸术后APE患者随机分为对照组(LMWH治疗)、观察组(在对照组的基础上联合华法林治疗)各45例。比较两组患者治疗前、后的凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fbg)、动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)和动脉血氧二氧化碳分压(PaCO2)。结果:对照组的PT、TT和Fbg表达水平高于观察组(P<0.05);对照组的PaO2和SaO2水平低于观察组(P<0.05),PaCO2高于观察组(P<0.05)。结论:LMWH联合华法林治疗开胸术后APE有利于改善凝血功能以及血气水平。
Objective:To investigate clinical curative effect of low molecular weight heparin(LMWH)combined with warfarin on acute pulmonary embolism(APE)after thoracotomy.Methods:90 patients with acute pulmonary embolism after thoracotomy were randomly divided into two groups:control group(treated with molecular heparin)and observation group(treated with warfarin on the basis of control group).,45 cases in each group.The prothrombin time(PT),thrombin time(TT),fibrinogen(Fbg),arterial partial pressure of oxygen(PaO2),arterial oxygen saturation(SaO2),arterial partial pressure of carbon dioxide(PaCO2).Results:The expression levels of PT,TT and Fbg in the control group were higher than those in the observation group(P<0.05),while levels of PaO2 and SaO2 were lower than those in the observation group(P<0.05),and PaCO2 was higher than that in the observation group(P<0.05).Conclusion:LMWH combined with warfarin is beneficial to improve coagulation function and blood gas level in the treatment of APE after thoracotomy.
作者
张启炎
ZHANG Qi-yan(Shangrao Municipal Hospital,Shangrao Jiangxi 334000,China)
出处
《药品评价》
CAS
2019年第22期44-45,共2页
Drug Evaluation
关键词
急性肺栓塞
低分子肝素
华法林
Acute Pulmonary Embolism
Low Molecular Weight Heparin
Warfarin
