摘要
目的 探讨血清降钙素原联合血小板平均体积检测对急性胰腺炎(AP)病情的预测价值。方法 选取2015年4月~2017年12月本院收治的急性胰腺炎患者134例为研究对象,根据AP分型标准分为轻症型、中度重症型和重症型三组,根据临床转归情况分为生存组和死亡组,比较不同AP分型、不同临床转归患者MPV、血清PCT水平及APACHEⅡ评分,ROC曲线评估PCT、MPV单独及联合检测判断AP预后的临床价值。结果 随着AP病情进展,患者 MPV、PCT及APACHEⅡ评分均呈升高趋势;死亡组MPV、PCT及APACHEⅡ评分均较生存组明显升高,差异有统计学意义(P<0.05);Pearson相关分析发现,MPV、PCT与APACHEⅡ评分均存在强正相关性(r=0.630、0.704,P<0.05);ROC曲线分析发现,MPV≥13.04 fL预测AP预后的灵敏度为88.9%,特异度为97.2%,AUC为0.972;PCT≥4.65 ng/mL预测AP预后的灵敏度为74.1%,特异度为92.5%,AUC为0.869;二者联合预测死亡的灵敏度为92.6%,特异度可达100.0%,AUC为0.990。结论 MPV、PCT水平可反映AP患者病情,且二者联合检测可作为AP预后的评价指标。
Objective To explore the value of serum procalcitonin and mean platelet volume (MPV) in prediction of prognosis of acute pancreatitis (AP).Methods One hundred and thirty four inpatients with acute pancreatitis were divided into light,moderate,and severe groups according to the criteria of classification,and subsequently divided into the survival group and the death group based on the clinical outcomes.The MPV,serum PCT level and APACHE II score in different severities and clinical outcomes were compared.The ROC curve was used to evaluate the clinical value of PCT,MPV,and combined detections to determine the prognosis of AP.Results With the progression of the disease,the levels of MPV,PCT and the score of APACHE II increased,showing a significant elevation in the cases of death group compared with those of the survival group (P<0.05).A strong positive correlation was noted between MPV and PCT and APACHE II scores (r=0.630,0.704,P<0.05).ROC curve analysis showed that the sensitivity,specificity,and AUC were 88.9%,97.2%,and 0.972,respectively if MPV≥13.04 fl was taken as the prediction cutoff value,whereas the sensitivity and specificity were found to be 74.1% and 92.5% when PCT≥4.65ng/ml was used as the prediction value.Conclusion of MPV with PCT examinations is promising for prediction of the outcomes of acute pancreatitis.
作者
石琼梅
惠朝晖
张永顶
龙国海
SHI Qiong-mei;HUI Chao-hui;ZHANG Yong-ding(Xili Hospital of Nanshan District,Shenzhen,Guangdong 518055)
出处
《临床输血与检验》
CAS
2020年第1期86-89,共4页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
降钙素原
血小板平均体积
急性胰腺炎
预后
Procalcitionin
Mean platelet volume
Acute pancreatitis
Prognosis
