摘要
目的探讨抗心磷脂抗体(anti cardiolipin antibody,ACL)、抗β2糖蛋白1(anti-β2 glycoprotein 1 antibodies,抗β2GP1)和同型半胱氨酸(homocysteine,Hcy)与自发性早产的关系。方法将2017年10月至2019年10月在本院接受治疗的68例自发性早产患者(均已自愿签署知情同意书)的临床资料组成观察组,同时随机抽取同期于本院足月、顺利分娩的37例产妇资料组成对照组,所有入选者均需采集静脉血及分娩后的胎盘组织,接受ACL、抗β2GP1与Hcy检测,分析检测结果与阳性率。结果观察组静脉血及分娩后的胎盘组织内ACL、抗β2GP1及Hcy水平均高于对照组,差异有统计学意义(P<0.05);观察组ACL、抗β2GP1、Hcy及联合检测阳性率均高于对照组,差异有统计学意义(P<0.05)。结论 ACL、抗β2GP1、Hcy与自发性早产具有一定关联,其检测水平明显高于足月顺产,将上述3项指标联合检测,可辅助临床及时明确患者病情并积极采取干预措施,以进一步改善早产预后风险。
Objective To investigate the correlation of anti cardiolipin antibody(ACL), anti-β2 glycoprotein 1(anti-β2 GP1) and homocysteine(Hcy) with spontaneous premature birth. Methods The clinical data of 68 patients with spontaneous premature birth(All have voluntarily signed informed consent form) who treated in the hospital from October 2017 to October 2019 were taken as observation group. The data of 37 full-term pregnant women with smooth childbirth were randomly selected from the hospital during the same period and taken as control group. The venous blood and placenta tissues after delivery of all selected cases were taken, and they received ACL, anti-β2 GP1 and Hcy detection. The detection results and positive rate were analyzed. Results The levels of ACL, anti-β2 GP1 and Hcy in venous blood and placenta tissues after delivery in observation group were higher than those in control group, and the difference was statistically significant(P<0.05);The positive rate of ACL, anti-β2 GP1, Hcy and joint detection in observation group was higher than that in control group, and the difference was statistically significant(P<0.05). Conclusion ACL, anti-β2 GP1 and Hcy have certain correlation with spontaneous premature birth, whose detection levels are significantly higher than those of full-term smooth childbirth. The joint detection of three indicators can help the clinic to identify patients’ conditions and actively take interventions in time, so as to further improve the prognostic risk of premature birth.
作者
刘颖群
郑绍军
郑芳
俞茜
蔡力红
Liu Yingqun;Zheng Shaojun;Zheng Fang;Yu Qian;Cai Lihong(Department of Obstetrics,Shangrao People's Hospital,Shangrao,Jiangxi,334000,China)
出处
《当代医学》
2020年第5期6-8,共3页
Contemporary Medicine
基金
江西省卫生健康委科技计划(20197453)
