摘要
目的检测反映早期肾功能改变的中性粒细胞明胶酶相关载脂蛋白(NGAL)的水平变化,探讨老年病人逆行胰胆管造影术(ERCP)前后肾功能变化及含碘造影剂对ERCP肾功能的影响。方法选取我院2017年10月至2018年12月收住消化医学中心的年龄≥60岁的接受逆行胰胆管造影术的51例病人为研究对象,收集病人术前及术后3 h、24 h、48 h血液及尿液标本,检测NGAL含量,同时检测术前及术后24 h、48 h的血肌酐、尿素氮并进行比较。结果 51例病人均完成经ERCP,术后血、尿NGAL各时间点与术前比较差异无统计学意义(P>0. 05);术后各时间点血肌酐、尿素氮与术前比较差异无统计学意义(P>0. 05)。结论 NGAL及血肌酐、尿素氮在老年病人ERCP术前后无明显变化,含碘造影剂对ERCP老年病人肾功能无明显影响,可以安全使用。
Objective To investigate the changes of neutrophil gelatinase-associated lipocalin( NGAL) which reflected early renal function changes in the elderly patients after endoscopic retrograde cholangiopancreatography( ERCP),and to investigate the effect of iohexol on the renal function in the elderly patients undergoing ERCP. Methods A total of 51 patients aged≥60 years old who received ERCP in our hospital from October 2017 to December 2018 were enrolled. Blood and urine were collected at pre-operation and 3 h,24 h and 48 h after the operation,and the levels of NGAL of the samples were measured. The serum levels of creatinine and urea nitrogen at pre-operation and 24 h,48 h after the operation were also detected and compared. Results All patients successfully performed ERCP. The blood and urine levels of NGAL afer operation were similar to those before operation( P> 0. 05);And the serum levels of creatinine and urea nitrogen after operation were also similar to those before operation( P>0. 05). Conclusions NGAL,serum creatinine and urea nitrogen show no significant changes in the elderly patients before and after ERCP. The iodinated contrast agent could be safely used in the elderly patients.
作者
王娟
杨丽华
WANG Juan;YANG Li-Hua(the Second Clinical Medical School of Nan-jing Medical University,Nanjing 210011,China;Department of Medical Center for Digestive Diseases,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)
出处
《实用老年医学》
CAS
2020年第1期28-31,共4页
Practical Geriatrics
关键词
中性粒细胞明胶酶相关载脂蛋白
逆行胰胆管造影术
肾功能
neutrophil gelatinase-associated lipocalin
endoscopic retrograde cholangiopancreatography
renal function
