摘要
膀胱癌是泌尿系统中最常见的恶性肿瘤,其中肌层浸润性膀胱癌(muscle-invasive bladder cancer,MIBC)的标准治疗手段是根治性膀胱切除术联合盆腔淋巴结清扫术。而近年来,放射治疗(放疗)在MIBC保留膀胱的治疗模式中起重要作用。该文就放疗在MIBC保留膀胱治疗中的应用进展进行综述,介绍了放疗在经尿道膀胱肿瘤电切术后辅助放疗和化学治疗的三联疗法中的应用进展、根治性放疗、术前放疗、放疗联合免疫治疗、放疗技术的发展与挑战、放疗相关不良反应,旨在为进一步探索更加科学有效的保留膀胱的综合治疗模式提供参考。
Bladder cancer is the most common malignant tumor in the urinary system.The standard treatment of muscle-invasive bladder cancer(MIBC)is the radical cystectomy combined with pelvic lymphadenectomy.In recent years,radiotherapy has played an important role in the MIBC bladder-preserving treatment model.This article will review the advances in the application of radiotherapy for bladder preservation in MIBC,and introduce the application progress of radiotherapy in trimodality therapy of adjuvant radiotherapy and chemotherapy after transurethral resection of bladder tumors,radical radiotherapy,preoperative radiotherapy,radiotherapy combined with immunotherapy,the development and challenges of radiotherapy technology,and radiotherapy-related adverse reactions.The aim of this article is to provide a reference for further exploration of a more scientific and effective comprehensive treatment mode for bladder preservation.
作者
缪延栋
沈亚丽
MIAO Yandong;SHEN Yali(Department of Abdominal Oncology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;The First School of Clinical Medicine,Lanzhou University,Lanzhou,Gansu 730000,P.R.China)
出处
《华西医学》
CAS
2020年第1期103-109,共7页
West China Medical Journal
基金
四川省科学技术厅科技计划项目(2019YJ0142)
关键词
肌层浸润性膀胱癌
放射治疗
保留膀胱
三联疗法
Muscular-invasive bladder cancer
Radiotherapy
Bladder preservation
Trimodality therapy
