期刊文献+

精神分裂症患者冠心病风险的因素分析 被引量:2

Risk factors for coronary heart disease in patients with schizophrenia
下载PDF
导出
摘要 目的:探讨精神分裂症患者冠心病风险的因素。方法:收集180例精神分裂症患者(病例组)的人口学及临床资料,并进行弗雷明汉10年冠心病风险评分,检测其血清甲状腺激素(TSH)、血清白蛋白(Alb)、总胆红素(TBIL)、三酰甘油(TG)、肌酐(Cr)、尿酸(UA)、尿素氮(BUN)水平;结果与性别和年龄相匹配的279名健康对照者(对照组)比较,分析精神分裂症患者冠心病风险的因素。结果:病例组冠心病风险(4.3%)明显高于对照组(2.3%),吸烟、合并高血压和糖尿病比率及收缩压、舒张压水平明显高于对照组(P<0.05或P<0.001)。与对照组相比,病例组血清Alb、TBIL、TC、HDL明显降低,TG和UA水平明显升高(P均<0.01);相关性分析显示病例组冠心病风险与其精神分裂症病程、治疗时长、发作次数及血清TG、BUN、UA水平呈正相关,与TSH水平呈负相关;线性回归分析显示,精神分裂症病程及血清TG、TSH水平与冠心病风险相关。结论:精神分裂症患者的冠心病风险升高;其病程及血清TG、TSH水平是其冠心病风险的影响因素。 Objective:To explore the risk factors for coronary heart disease(CHD)in patients with schizophrenia.Method:One hundred and eighty schizophrenic patients(case group)were enrolled with their demographic and clinical data,also their Framingham risk scores were performed;serum levels of thyroid hormone(TSH),serum albumin,total bilirubin(TBIL),triglyceride(TG),creatinine(Cr),uric acid(UA),and urea nitrogen(BUN)were detected.The results were compared with control group(179 healthy controls matched by sex and age).Results:The risk of coronary heart disease(4.3%)in the patient group was significantly higher than that in the control group(2.3%).The ratio of smoking,hypertension,diabetes mellitus,systolic blood pressure,and diastolic blood pressure were significantly higher than those in the control group(P<0.05 or P<0.001).Compared with the control group,in the case group the levels of serum Alb,TBIL,TC,HDL were significantly lower,TG and UA were significantly higher(all P<0.01).Correlation analysis showed that risk of CHD in the case group was positively correlated with the illness duration,treatment duration,frequency of onset and serum TG,BUN and UA levels,while negatively correlated with TSH levels.Linear regression analysis showed that the illness duration,and serum TG and TSH levels were correlated with the risk of CHD.Conclusion:Patients with schizophrenia present increased risk for CHD.Illness duration,serum levels of TG and TSH were the risk factors of CHD.
作者 周莉娜 马青艳 范雅娟 何潇言 赵斌斌 王崴 陈策 陈云春 马现仓 ZHOU Li-na;MA Qing-yan;FANYa-juan;HE Xiao-yan;ZHAO Bin-bin;WANG Wei;CHEN Ce;CHEN Yun-chun;MA Xian-cang(Department of Psychiatry,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,Chinaa)
出处 《临床精神医学杂志》 2020年第1期47-49,共3页 Journal of Clinical Psychiatry
基金 陕西省重点研发计划(2017ZDXM-SF-25-6) 陕西省创新能力支撑计划(2017KCT-20)
关键词 精神分裂症 冠心病风险 弗雷明汉风险评分 schizophrenia coronary heart disease risk Framingham risk score
  • 相关文献

二级参考文献8

共引文献13

同被引文献6

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部