摘要
目的研究二甲双胍对奥氮平治疗精神分裂症患者体质量增加及糖脂代谢紊乱的应用疗效。方法选取2017年3月-2019年6月我院收治的精神分裂症患者80例,按1:1比例随机分组,A组单用奥氮平治疗,B组在A组用药基础上予以二甲双胍治疗,比较两组体质量及糖脂代谢等指标。结果治疗前,两组体质量指数以及各项糖脂代谢指标比较差异无统计学意义,P> 0.05;治疗后,B组的体质量指数及各项糖脂代谢指标较A组均更占优势,P <0.05,差异有统计学意义。结论二甲双胍配合奥氮平能够有效避免精神分裂症患者体质量增加,减轻机体的糖脂代谢紊乱。
Objective To investigate the efficacy of metformin in the increase of body mass and glucose and lipid metabolism disorders in schizophrenia patients caused by olanzapine. Methods 80 patients with schizophrenia treated in our hospital from March 2017 to June 2019 were randomly divided into two groups with 1: 1 ratio. Group A was treated with olanzapine alone, and group B was treated with metformin based on the medication in group A. The indexes of body mass and glucose and lipid metabolism between two groups were compared. Results Before treatment, the body mass index and various glucose and lipid metabolism indexes of the two groups were relatively small, P > 0.05, there was no statistical significance;after treatment, the body mass index and various glucose and lipid metabolism indexes of group B were better than those in group A, P < 0.05, which was statistically significant. Conclusion The use of metformin in combination with olanzapine can effectively avoid the increase in body weight of patients with schizophrenia and ease the body’s glucose and lipid metabolism disorders.
作者
杜浩然
DU Haoran(The First District of Psychiatry Department,Shantou Fourth People's Hospital,Shantou Guangdong 515021,China)
出处
《中国卫生标准管理》
2020年第2期58-60,共3页
China Health Standard Management
基金
汕头市科技计划医疗卫生类别项目(180613164010293)
关键词
二甲双胍
奥氮平
精神分裂症
体质量
糖脂代谢
疗效
metformin
olanzapine
schizophrenia
body mass
glucose and lipid metabolism
efficacy
