摘要
目的探究血清胱抑素C(Cys C)、同型半胱氨酸(Hcy)水平与原发性高血压病患者靶器官损伤的关系。方法回顾性选择2014年9月至2017年12月西宁市第一人民医院心血管内科收治的原发性高血压患者纳入研究。收集患者一般资料,测定患者Hcy、Cys C、内生肌酐(Ccr)、颈动脉内膜中层厚度(c IMT)、左室质量指数(LVMI)等指标,比较不同高血压分级(高血压1级22例;高血压2级30例,高血压3级37例)及不同高血压类型患者(非H型高血压组41例及H型高血压组48例)各指标差异,分析血清Cy Sc、Hcy水平与靶器官损伤指标间的相关性。结果高血压患者LVMI、c IMT及血清Hcy、Cys C水平随高血压严重程度增加而升高(P <0. 05);血清Ccr水平随血压分级升高而递减,差异具有统计学意义(P <0. 05);H型高血压患者Hcy、Cys C、LVMI及c IMT显著高于非H型高血压患者(P <0. 05);Ccr水平显著低于非H型高血压患者,差异具统计学意义(P <0. 05);Pearson相关性分析示,血清Hcy与c IMT、LVMI呈正相关(P <0.05),与Ccr呈负相关(P <0.05);血清Cys C与LVMI呈正相关(P <0.05),与Ccr呈负相关(P <0. 05)。结论血清Cy Sc、Hcy水平与原发性高血压病患者靶器官损害相关,可作为反映靶器官损伤的参考指标。
Objective To investigate the relationship between levels of serum cystatin C( CysC),homocysteine( Hcy) and target organ damage in patients with essential hypertension. Methods Patients with essential hypertension admitted to the Vasculocardiology Department of the hospital from September 2014 to December 2017 were enrolled in the study. The general data of patients were collected. The Hcy,CysC,endogenous creatinine( Ccr),carotid intima-media thickness( c IMT),left ventricular mass index( LVMI) and other indicators were measured. The differences of all indicators in patients with different hypertension grades and types were compared. The correlation between levels of serum CySc,Hcy and target organ damage indicators was analyzed. Results The LVMI,c IMT and levels of serum Hcy and CysC in patients with hypertension increased with the severity of hypertension( P < 0. 05). The serum Ccr level decreased with the increase of hypertension grades( P < 0. 05).Hcy,CysC,LVMI and c IMT were significantly higher in H-type hypertensive patients than those in non-H-type hypertensive patients( P <0. 05),while Ccr levels were significantly lower than those in non-H-type hypertensive patients( P < 0. 05). Pearson correlation analysis showed that serum Hcy was positively correlated with c IMT and LVMI( P < 0. 05),negatively correlated with Ccr( P < 0. 05). Serum CysC was positively correlated with LVMI( P < 0. 05),negatively correlated with Ccr( P < 0. 05). Conclusion The levels of serum CySc and Hcy are related to target organ damage in patients with essential hypertension,which can be used as a reference index to reflect target organ damage.
作者
张辉
才让
祁蕙燕
王永芹
韩永洁
ZHANG Hui;CAI Rang;QI Hui-yan(Department of Laboratory,Xining First People's Hospital,Xining Qinghai 810000,China)
出处
《临床和实验医学杂志》
2020年第4期363-366,共4页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金资助项目(No.81260451)
