摘要
目的观察艾司西酞普兰联合胰岛素治疗2型糖尿病合并抑郁患者临床效果及对抑郁症状、血糖水平影响。方法选取2型糖尿病合并抑郁138例,按照治疗方案不同将其分为观察组和对照组两组各69例。所有患者均常规控制饮食,观察组采用艾司西酞普兰联合胰岛素治疗,对照组仅采用胰岛素治疗。两组治疗时间均为8周。比较两组治疗后临床效果,治疗前后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分和血糖指标,以及治疗过程中不良反应发生情况。结果治疗后,观察组总有效率为89.86%高于对照组总有效率75.36%,差异有统计学意义(P<0.05)。治疗前,两组HAMA、HAMD评分及血糖指标比较差异无统计学意义(P>0.05)。治疗后,HAMA、HAMD评分及血糖指标两组均较治疗前降低,观察组低于对照组,差异有统计学意义(P<0.05或P<0.01)。治疗过程中,观察组出现头晕2例,恶心、口干及出汗各1例,总不良反应发生率7.25%;对照组出现头晕及恶心各1例,口干2例,总不良反应发生率5.80%,两组总不良反应发生率比较差异无统计学意义(P>0.05)。结论艾司西酞普兰联合胰岛素治疗2型糖尿病合并抑郁患者效果显著,能够控制患者抑郁症状和血糖水平,且不增加不良反应发生率。
Objective To observe the clinical effect of escitalopram combined with insulin in the treatment of patients with type 2 diabetes mellitus(T2 DM) complicated with depression and its effect on depressive symptoms and blood glucose levels. Methods A total of 138 patients with T2 DM complicated with depression were selected. All patients were divided into observation group(n=69) and control group(n=69), according to different treatment methods. The diet of all patients were routinely controlled. The observation group was treated with escitalopram combined with insulin, while the control group was merely treated with insulin. Patients in both groups were treated for 8 weeks. The clinical effects after treatment, the Hamilton Depression Scale(HAMD), the Hamilton Anxiety Scale(HAMA) score and blood glucose indexes before and after treatment, and the incidence of adverse reactions during treatment between the two groups were compared. Results After treatment, the total effective rate in the observation group was 89.86%, which was significantly higher than that(75.36%) in the control group(P<0.05). Before treatment, there was no significant difference in HAMA, HAMD scores and blood glucose indexes between the two groups(P>0.05). After treatment, the HAMA, HAMD score and blood glucose indexes were significantly lower in both groups than those before treatment, and the indicators in observation group was significantly lower than those in the control group(P<0.05 or P<0.01). During the treatment, there were 2 cases with dizziness, 1 case with nausea, 1 case with dry mouth, and 1 case with sweating, and the total incidence of adverse reactions was 7.25% in the observation group. In the control group, there was 1 case with dizziness, 1 case with nausea, 2 cases with dry mouth, and total adverse reaction was 5.80%, which, however, did not differ significantly in both groups(P>0.05). Conclusion The efficacy of escitalopram combined with insulin in the treatment of T2 DM patients with depression is significant, and it can effecti
作者
高兴
刘海燕
陈丽萍
孟浩
耿可念
潘艳芬
李丽
GAO Xing;LIU Hai-yan;CHEN Li-ping;MENG Hao;GENG Ke-nian;PAN Yan-fen;LI Li(Department of Psychiatry,Hengshui Psychiatric Hospital,Hengshui,Hebei 053800,China;Department of Internal Medicine,Hengshui Psychiatric Hospital,Hengshui,Hebei 053800,China;Department of Traditional Chinese Medicine,Hengshui Psychiatric Hospital,Hengshui,Hebei 053800,China;Department of Psychiatry,Hebei Province Veterans Hospital,Baoding,Hebei 071000,China)
出处
《临床误诊误治》
2020年第2期42-46,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省中医药管理局科研计划项目(2019350)
