摘要
泛素特异性蛋白酶10(USP10)是去泛素化酶(DUB)家族中的重要成员之一,该酶主要通过泛素依赖的蛋白分解代谢、泛素周期等途径调控细胞增殖、凋亡,DNA损伤修复,炎症反应等过程。另外,USP10在多种癌症发生发展中的重要作用越来越受关注。现就USP10与常见癌症的诊治与预后的研究现状进行综述,以期发现与USP10相关的某些关键的分子机制,为癌症诊断与治疗提供参考。
Ubiquitin-specific protease10(USP10) is one of the important members of the deubiquitinating enzyme familyinvolved in the regulation of cellular biological processes,such as cell proliferation,apoptosis,DNA damage repair and inflammation response.The important role of USP10 in the occurrence and development of cancers gains more and more recognition.Here,the research progress in tumorigenesis of USP10 was reviewed to discover some key molecular mechanisms associated with USP10 and provide diagnostic and therapeutic ideas for cancers.
作者
成迎迎
黄小英
龙喜带
CHENG Yingying;HUANG Xiaoying;LONG Xidai(Center for Clinical Pathology Diagnosis and Research of Affiliated Hospital,Youjiang Medical University for Nationalities,Youjiang Medical University for Nationalities,Baise 533000,China;Department of Pathology of Affiliated Hospital,Youjiang Medical University for Nationalities,Baise 533000,China)
出处
《右江医学》
2020年第1期7-11,共5页
Chinese Youjiang Medical Journal
基金
国家自然科学基金(81860489,81760502,81572353,81472243,81660495,81460423)
广西自然科学基金(2018GXNSFAA281043,2017GXNSFAA198002,2017GXNSFGA198002,2016GXNSFDA380003)
广西特聘专家(厅发[2017]40号)
广西高校卓越学者专项科研课题(桂教人[2017]38号)
广西教育科学“十二五”规划课题(2015C397)
广西研究生教育创新计划项目(JGY2015139)
