摘要
目的探讨质子泵抑制剂的临床不良反应和合理用药,以提高临床治疗效果。方法选取我院于2017年12月-2018年12月收治的129例住院患者,回顾性分析其临床资料观察常见的不良反应。按不同质子泵抑制剂的使用分为奥美拉唑组、泮托拉唑组、雷贝拉唑组,每组各43例,比较两组患者的临床治疗总有效率、不良反应发生率等结果。结果质子泵抑制剂的常见不良反应有皮肤过敏、消化系统不良、精神系统损害、呼吸系统不良;三组之间的治疗总有效率均较高,且差异无统计学意义(P>0.05);三组之间的不良反应发生率均较低,且奥美拉唑组比其他都低(P<0.05)。结论质子泵抑制剂存在不良反应,临床用药上应该加强用药合理性,奥美拉唑的不良反应发生率较低,配合其他药物效果显著,能提高临床治疗效果。
Objective To investigate the clinical adverse reactions and rational use of proton pump inhibitors in order to improve the clinical treatment effect.Methods A total of 129 inpatients admitted to our hospital from December 2017 to December 2018 were retrospectively analyzed for clinical data to observe common adverse reactions.According to the use of different proton pump inhibitors,it was divided into omeprazole group,pantopl group and rabeprazole group,with 43 cases in each group.The total effective rate of treatment and the incidence of adverse reactions were compared between the two groups.Results The common adverse reactions of proton pump inhibitors were skin allergy,poor digestive system,mental system damage and poor respiratory system.The total effective rate of treatment among the three groups was higher,and the difference was not significant(P>0.05).The incidence of adverse reactions between the groups was low,and the omeprazole group was lower than the other groups(P<0.05).Conclusion There are adverse reactions in proton pump inhibitors.The rationality of drug use should be strengthened in clinical use.The incidence of adverse reactions of omeprazole is low.The effect of other drugs is remarkable,which can improve the clinical treatment effect.
作者
陆燕
LU Yan(Department of Pharmacy,Xiaogan Central Hospital,Xiaogan Hubei 432000,China)
出处
《中国继续医学教育》
2020年第3期112-113,共2页
China Continuing Medical Education
关键词
质子泵抑制剂
不良反应
临床合理用药
奥美拉唑
泮托拉唑
兰索拉唑
proton pump inhibitor
adverse reactions
clinical rational use of drugs
omeprazole
pantoprazole
lansoprazole
