摘要
目的探讨不同PS首剂量对近足月早产NRDS患儿临床疗效和安全性的影响。方法选择2013年1月至2019年1月在我院就诊的近足月早产NRDS患儿120例。按照随机数字表法将患儿分为研究组和对照组,各60例。对照组患儿入院6小时内给予牛肺表面活性物质70mg/kg气管内注入,研究组患儿入院后6小时内给予100mg/kg牛肺表面活性物质气管注入治疗,记录两组患儿吸氧时间、治疗期间氧合指数、机械通气时间、PS二次使用率、住院时间、肺顺应性、动脉血氧分压、动脉二氧化碳分压等情况。记录两组患儿病死率和并发症发生情况。结果研究组患儿机械通气时间、PS二次使用率、住院时间、吸氧时间显著低于对照组(P<0.05);治疗后6h,两组患儿氧合指数、PaCO 2、PaO 2肺顺应性均显著高于治疗前,且研究组均显著高于对照组(P<0.05),治疗后12h,两组患儿氧合情况及血气分析情况比较,差异无统计学意义(P>0.05);研究组PDA发生率显著高于对照组(P<0.05),但两组患儿肺出血、颅内出血、肺气漏、反复呼吸暂停、ROP、NEC、BPD、PVL及死亡率比较,差异无统计学意义(P>0.05)。结论高剂量PS首次给药能够显著提高近足月早产NRDS患儿临床疗效,且具有较好的安全性,值得临床推广。
Objective To investigate the effect of different initial doses of PS on the clinical efficacy and safety of near-term preterm NRDS children.Methods 120 cases of full-term premature NRDS from January 2013 to January 2019 were selected.According to the random number table method,the children were divided into the study group and the control group,60 cases in each group.The control group was given 70 mg/kg bovine pulmonary surfactant intratracheal injection within 6 hours of admission,and the study group was given 100 mg/kg bovine pulmonary surfactant intratracheal injection within 6 hours after admission.The oxygen uptake time,oxygen index during treatment,mechanical ventilation time,secondary use rate of PS,hospital stay,pulmonary compliance,arterial oxygen partial pressure,and arterial carbon dioxide were recorded.The mortality and complications of the two groups were recorded.Results The mechanical ventilation time,PS secondary utilization rate,hospitalization time and oxygen uptake time in the study group were significantly lower than those in the control group(P<0.05).6 hours after treatment,the oxygenation index,PaCO 2 and PaO 2 lung compliance in the two groups were significantly higher than those before treatment,and the study group was significantly higher than those in the control group(P<0.05).12 hours after treatment,there was no significant difference in oxygen and blood gas analysis between the two groups.The incidence of PDA in the study group was significantly higher than that in the control group(P<0.05),but there was no significant difference in pulmonary hemorrhage,intracranial hemorrhage,pneumoconiosis,repeated apnea,ROP,NEC,BPD,PVL and mortality between the two groups(P>0.05).Conclusion The first administration of high dose PS can significantly improve the clinical efficacy of preterm infants with NRDS,and has higher safety,which is worthy of widely clinical promotion.
作者
周敏
刘翠兰
雷玉琳
邹红英
ZHOU Min;LIU Cui-lan;LEI Yu-lin;ZOU Hong-ying(Guang’an People's Hospital,Guangan,Sichuan 638000,China)
出处
《临床肺科杂志》
2020年第2期240-243,共4页
Journal of Clinical Pulmonary Medicine
关键词
牛肺表面活性物质
近足月早产
新生儿呼吸窘迫综合征
bovine pulmonary surfactant
near term preterm delivery
neonatal respiratory distress syndrome
