摘要
目的观察益气明目丸对视网膜色素变性(RP)患者眼部血流动力学的影响。方法采用前瞻性随机对照试验的研究方法,观察2017年10月-2019年1月在湖南中医药大学第一附属医院眼科、长沙市中医院眼科门诊就诊的RP患者70例(140只眼),随机分为治疗组与对照组各35例,分别予以维生素E或益气明目丸口服治疗3月。检测患者的视网膜电图(ERG)、睫状后短动脉收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)及搏动指数(PI)等进行疗效评价。结果治疗后2组暗适应及明适应ab波振幅、EDV、RI、PI较治疗前有明显改善(P<0.05),治疗组优于对照组(P<0.05)。结论益气明目丸能提高RP患者明、暗适应ab波振幅,降低眼部血流阻力,增加视网膜血流量,这可能是益气明目丸治疗RP的机制之一。
OBJECTIVE To observe the effect of Yiqi Mingmu pill on hemodynamics for patients with retinitis pigmentosa(RP).METHODS The prospective randomized control study was applied to observe 70 RP patients(140 eyes)admitted in the First Hospital of Hunan University of Chinese Medicine and Changsha Hospital of Traditional Chinese Medicine,who were randomly divided into the control group(35 cases)and the treatment group(35 cases),given vitamin E and Yiqi Mingmu pill oral liquid for three months res.The effect analysis was estimated from electroretinogram(ERG),peak systolic velocity(PSV)of short posterior ciliary arteries,end-diastolic velocity(EDV),resistance index(RI)and pulsatility index(PI).RESULTS After treatment,indexes of both groups have significantly improved(P<0.05).In the comparison of two groups’ ab wave amplitude of dark and light adaptation,EDV,RI and PI,the difference is statistically significant(P<0.05).CONCLUSION Yiqi Mingmu pill can improve RP patients’ ab wave amplitude of dark and light adaptation,reduce the ocular blood flow resistance and promote retinal blood flow,which could be the mechanism of Yiqi Mingmu pill treating RP.
作者
蒋鹏飞
彭俊
曾志成
姚小磊
彭晓芳
彭清华
李传课
JIANG Peng-fei;PENG Jun;ZENG Zhi-cheng;YAO Xiao-lei;PENG Xiao-fang;PENG Qing-hua;LI Chuan-ke(Center for Oculopathy and Protecting Visual Function,Hunan University of ChinesE-Medicine,Changsha,410208,China;ThE-First Hospital of Hunan University of ChinesE-Medicine,Changsha,410007,China;Ophthalmology Department,Changsha Hospital of Traditional ChinesE-Medicine,Changsha,410100,China)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2020年第1期24-27,共4页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金(81804150)
中医药防治五官科疾病湖南省重点实验室建设项目(2017TP1018)
长沙市科技计划项目(K1501014-31,kc1704005)
国家中医药管理局中医眼科学重点学科建设项目(ZK1801YK015)
湖南中医药大学中医学国内一流建设学科(2018年)
湖南省研究生科研创新项目(CX2018B497)
湖南省自然科学基金(2019JJ40226)
