摘要
目的探讨2型糖尿病(T2DM)合并骨质疏松的影响因素。方法选取151例T2DM住院患者,采用双能X线骨密度仪测定腰椎1~4椎体及股骨近端的骨密度,根据T值分为骨量正常组40例、骨量减少组68例、骨质疏松组43例。比较3组临床资料及生化指标,采用多因素Logistic回归对T2DM合并骨质疏松的影响因素进行分析。结果骨量正常组、骨量减少组、骨质疏松组T2DM患者的性别、年龄、BMI、糖尿病病程、空腹胰岛素、空腹C肽、ALT、空腹血糖、血清肌酐、TSH、碱性磷酸酶比较差异均有统计学意义(P均<0.05)。多因素Logistic回归分析显示,BMI、糖尿病病程均为T2DM合并骨质疏松的影响因素(P均<0.05)。结论糖尿病病程、BMI为T2DM合并骨质疏松的影响因素,应关注糖尿病病程较长及BMI较低的T2DM患者,积极防治骨质疏松。
Objective To explore the influence factors of type 2 diabetes mellitus(T2DM) complicated with osteoporosis. Methods A total of 151 hospitalized patients with T2DM were selected. The bone mineral density(BMD) of lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry. According to the T value, all patients were divided into normal bone mass group(n=40), bone mass reduction group(n=68) and osteoporosis group(n=43). Clinical data and biochemical parameters were statistically compared among three groups. The influence factors of T2DM complicated with osteoporosis were analyzed by multivariate Logistic regression model. Results The gender, age, body mass index(BMI), course of T2DM, fasting insulin level, fasting C peptide level, ALT, fasting blood glucose, serum creatinine, TSH and alkaline phosphatase significantly differed among three groups(all P<0.05). Multivariate Logistic regression analysis demonstrated that BMI and course of T2DM were the influence factors of T2DM complicated with osteoporosis(both P<0.05). Conclusions The course of T2DM and BMI are the influence factors of T2DM complicated with osteoporosis. Extensive attention should be paid to T2DM patients with longer course of T2DM and lower BMI to actively prevent and treat osteoporosis.
作者
吕茵
周围
何文娜
李凤棉
潘立群
胡元元
王成
Lyu Yin;Zhou Wei;He Wenna;Li Fengmian;Pan Liqun;Hu Yuanyuan;Wang Cheng(Department of Nuclear Medicine,Shunde Hospital of Southern Medical University,Foshan 528300,China)
出处
《新医学》
2020年第1期33-36,共4页
Journal of New Medicine
基金
广东省医学科研基金（A2017174）
关键词
2型糖尿病
骨质疏松
影响因素
骨密度
Type 2 diabetes mellitus
Osteoporosis
Influence factor
Bone mineral density
