摘要
目的探讨桂枝芍药知母汤联合氨甲蝶呤对类风湿关节炎患者的影响。方法选取2016年9月至2018年9月该院收治的类风湿关节炎患者230例作为研究对象,根据治疗方案不同分为3组,对照1组采用氨甲蝶呤治疗,对照2组采用桂枝芍药知母汤治疗,研究组采用桂枝芍药知母汤联合氨甲蝶呤治疗。比较3组患者疗效、晨僵持续时间、关节压痛个数、关节肿胀个数、健康评分(HAQ)、医生总体评分、患者总体评分、疼痛评分。结果研究组患者疗效均优于对照1组和对照2组,差异均有统计学意义(P<0.05);治疗后,研究组患者晨僵持续时间、关节压痛个数、关节肿胀个数均少于对照1组和对照2组,差异均有统计学意义(P<0.05);治疗后,研究组患者HAQ、医生总体评分、患者总体评分均高于对照1组和对照2组,疼痛评分低于对照1组和对照2组,差异均有统计学意义(P<0.05);研究组患者不良反应发生率均低于对照1组和对照2组,差异均有统计学意义(P<0.05)。结论采用桂枝芍药知母汤联合氨甲蝶呤治疗类风湿关节炎疗效优于桂枝芍药知母汤或氨甲蝶呤单独应用,值得临床推广应用。
Objective To investigate the effect of Guizhi Shaoyao Zhimu Decoction combined with methotrexate on pain symptoms in patients with rheumatoid arthritis.Methods A total of 230 patients with rheumatoid arthritis admitted to our hospital from September 2016 to September 2018 were enrolled.According to the treatment plan,they were divided into 3 groups.The control group 1 was treated with methotrexate,and the control group 2 was treated with Guizhi Shaoyao Zhimu Decoction,the research group was treated with Guizhi Shaoyao Zhimu Decoction combined with methotrexate.The efficacy,morning stiffness,joint tenderness,joint swelling,health score(HAQ),overall doctor score,overall patient score,pain score,rheumatoid factor(RF)in three groups.Results The curative effect of the study group was significantly higher than that of the control group 1 and the control group 2(P<0.05).The duration of morning stiffness,the number of joint tenderness,and the number of joint swelling in the study group were significantly less than those in the control group 1 and the control group 2(P<0.05).The study group′s health score(HAQ),doctor′s overall score,and overall patient score were significantly higher than those in control group 1 and control group 2(P<0.05).The pain score of the study group was significantly lower than that of control group 1 and control group 2(P<0.05).The rate of adverse reactions in research group was significantly lower than that of control group 1 and control group 2(P<0.05).Conclusion In the treatment of rheumatoid arthritis,the efficacy of Guizhi Shaoyao Zhimu Decoction combined with methotrexate is better than that of Guizhi Shaoyao Zhimu Decoction or methotrexate alone.It should be widely promoted and applied in clinical practice.
作者
奚娜
张军文
XI Na;ZHANG Junwen(Department of Blood Rheumatology,Hematology and Rheumatology,People′s Hospital of Hanzhong,Hanzhong,Shaanxi 723000,China;Department of Rehabilitation and Traditional Chinese Medicine,People′s Hospital of Hanzhong,Hanzhong,Shaanxi 723000,China)
出处
《检验医学与临床》
CAS
2020年第2期195-198,共4页
Laboratory Medicine and Clinic
关键词
桂枝芍药知母汤
氨甲蝶呤
类风湿关节炎
疼痛
关节
Guizhi Shaoyao Zhimu Decoction
methotrexate
rheumatoid arthritis
pain
joints
