摘要
目的:采用MRI方法研究常见心脑血管疾病高危因素与脑铁沉积的关系。方法:纳入84名无神经系统疾病和脑外伤的社区中老年人,全面评估其心脑血管疾病高危因素,行MRI检查获取高清T1加权图像及T2^*加权三维梯度回波序列(ESWAN)图像,ESWAN图像后处理得R2^*图,采用计算机分割技术对高清T1加权图像进行组织分割,配准至ESWAN图像后,提取各脑区的R2^*值。采用多元线性回归分析揭示中老年人性别、年龄、心脑血管疾病高危因素对各脑区R2^*值的影响。结果:海马、脑白质、脑皮质R2^*值升高与吸烟有关(β值分别为0.244、0.317、0.277,P<0.05或P<0.01);壳核R2^*值升高与高血压有关(β值为0.241,P<0.05);丘脑R2^*值升高与高血糖有关(β值为0.234,P<0.05);男性丘脑R2^*值高于女性(β值为0.320,P<0.05);丘脑、尾状核、苍白球、脑白质、脑皮质等R2^*值与年龄相关(β值分别为-0.218、-0.254、0.216、-0.280和-0.238,P<0.05或P<0.01)。结论:常见心脑血管疾病高危因素可能导致脑铁沉积,且不同因素引起的铁沉积模式不同。
Objective:To study the correlation of common cardiovascular risk factors with brain iron deposition.Methods:Eighty-four elderly subjects without neurological diseases or brain trauma were included in the study.The cardiovascular risk factors were comprehensively assessed.MRI examination was performed to obtain high-resolution T1-weighted images and enhanced susceptibility weighted angiography(ESWAN)images,and R2^*figure was obtained by post-processing the ESWAN sequence.High definition T1 images were segmented using computer segmentation technique.After registration to the ESWAN image,R2^*values of each region of interest were extracted.Multiple linear regression analysis was used to analyze the relationship of R2^*values in each area of interest with gender,age and vascular risk factors.Results:Smoking was associated with increased R2^*values in the hippocampus,white matter and cortex(β=0.244,0.317,0.277,P<0.05 or P<0.01).Hypertension was correlated with the increase of R2^*in the putamen(β=0.241,P=0.027).Hyperglycemia was associated with the increase of R2^*in the thalamus(β=0.234,P<0.05).In the thalamus,the R2^*value of males was higher than that of females(β=0.320,P<0.05).Age was correlated with the R2^*values of thalamus,caudate nucleus,pallidus,white matter and cortex(β=-0.218、-0.254、0.216、-0.280 and-0.238,P<0.05 or P<0.01).Conclusion:Common cardiovascular risk factors may lead to iron deposition in the brain,and the deposition patterns vary with the gender,age and different risk factors.
作者
胡琳琳
张睿婷
王淑玥
洪慧
黄沛钰
张敏鸣
HU Linlin;ZHANG Ruiting;WANG Shuyue;HONG Hui;HUANG Peiyu;ZHANG Minming(Department of Radiology,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Radiology,Jinhua Central Hospital,Jinhua 321000,Zhejiang Province,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2019年第6期644-650,共7页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金(81771820)
浙江省自然科学基金(LSZ19H180001)
关键词
心血管疾病/病因学
卒中/病因学
危险因素
铁/代谢
磁共振成像
Cardiovascular diseases/etiology
Stroke/etiology
Risk factors
Iron/metabolism
Magnetic resonance imaging
