摘要
目的分析肾结石患者尿液纳米细菌(NB)感染与尿液成石危险因素的关系。方法:检测我院2016年1月至2019年2月1210例单侧肾结石患者的肾盂尿液NB浓度,根据纳米细菌浓度分为组1(0个/视野)、组2(1~2个/视野)和组3(≥3个/视野)共3组;同时收集各组患者结石侧24 h尿液,进行尿液成石危险因素检测,比较各组患者尿钙浓度、尿镁浓度、尿枸橼酸浓度、尿草酸浓度、尿尿酸浓度的差异。结果组1、组2、组3患者结石侧24 h尿钙浓度分别为(74.959±21.664)、(94.354±28.579)、(92.998±23.26)mg/24 h,组1 vs.组2、组1 vs.组3差异均具有统计学意义(P=0.021,P=0.015)。尿镁浓度分别为(69.349±22.086)、(68.645±26.699)、(65.887±21.126)mg/24 h,尿枸橼酸浓度分别为(224.512±102.675)、(228.283±88.409)、(234.905±95.226)mg/24 h,尿草酸浓度分别为(36.714±11.131)、(38.735±12.416)、(37.561±15.182)mg/24 h,尿尿酸浓度分别为(35.691±11.891)、(37.958±15.889)、(36.902±13.606)mg/24 h,尿镁、尿枸橼酸、尿草酸以及尿尿酸3组间比较,差异均无统计学意义(P均> 0.05)。结论肾结石患者尿液NB感染与尿液成石危险因素之间关系密切。尿液NB感染可通过升高尿钙浓度增加尿液成石危险因素。
Objective To analyze the relationship between nanobacterial infection and the risk factors for stone formation in patients with kidney stones. Methods A total of 1210 patients with unilateral kidney stones treated at our hospital from January 2016 to February 2019 were recruited in this study. Urine nanobacteria were detected, and the patients were divided into three groups according to the count of nanobacteria: group 1(0/field), group 2(1-2/field), and group 3( ≥ 3/field). 24-hour urine was collected to detect the risk factors for stone formation. Urine calcium, oxalic acid, uric acid, citric acid, and magnesium concentrations were compared between groups. Results The urinary calcium concentration in groups 1-3 was(74.959±21.664),(94.354±28.579), and(92.998±23.26) mg/24 h, respectively, and it was significantly higher in group 2 or 3 than in group 1(P=0.021 and P=0.015, respectively). In groups 1-3, the concentration of magnesium was(69.349±22.086),(68.645±26.699), and(65.887±21.126) mg/24 h, the concentration of citric acid was(224.512±102.675),(228.283±88.409), and(234.905±95.226) mg/24 h, the concentration of oxalic acid was(36.714±11.131),(38.735±12.416), and(37.561±15.182) mg/24 h, and the concentration of uric acid was(35.691±11.891),(37.958±15.889), and(36.902±13.606) mg/24 h, respectively, and there was no significant difference among the three groups with regard to magnesium, citric acid, oxalic acid, and uric acid concentrations(P > 0.05 for all). Conclusion Nanobacterial infection is closely associated with the risk factors for stone formation in patients with kidney stones. Nanobacterial infection increases the risk of stone formation by increasing urinary calcium concentration.
作者
韩跃辅
彭潋
方海林
黄洪才
陈东
Han Yuefu;Peng Lian;Fang Hailin;Huang Hongcai;Chen Dong(Department of Urology,Shantou University Medical College Affiliated Yuebei People′s Hospital,Shaoguan 512026,China)
出处
《中华临床医师杂志（电子版）》
CAS
2019年第5期339-342,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
广东省韶关市卫生计生科研项目(Y18036)
关键词
纳米细菌
肾结石
成石危险因素
尿钙浓度
Nanobacteria
Kidney stones
Risk factors for stone formation
Urinary calcium concentration
