摘要
目的:探讨乌拉地尔治疗高血压伴急性心力衰竭的效果及对心功能、NT-proBNP的影响。方法:将60例高血压伴急性心力衰竭患者按照研究方法的不同分为对照组(采用硝酸异山梨酯进行治疗)与观察组(采用乌拉地尔进行治疗),每组各30例,对比治疗效果。结果:观察组治疗后NT-proBNP、丙氨酸转氨酶、天冬氨酸转氨酶、肌酐均低于对照组,且LVEF高于对照组(P<0.05);观察组干预后各时间点心率、血压、不良反应发生率均低于对照组(P<0.05)。结论:乌拉地尔治疗高血压伴急性心力衰竭的效果显著,心功能改善作用明显,有效降低NT-proBNP水平,不良反应发生率低,可改善病人的血压和心率。
Objective: To investigate the effect of urapidil on hypertension with acute heart failure and its effect on cardiac function and nt-probnp. Methods: Sixty patients with hypertension and acute heart failure were divided into a control group(treated with isosorbide nitrate) and an observation group(treated with uradil), with 30 cases in each group, and the treatment effects were compared. Results: After treatment, nt-probnp, alanine transaminase, aspartate transaminase and creatinine in the observation group were all lower than those in the control group, and LVEF was higher than those in the control group(P<0.05). The rates of heart rate, blood pressure and adverse reactions in the observation group were lower than those in the control group(P<0.05). Conclusion: Urapidil treatment of hypertension with acute heart failure is significant, cardiac function improvement effect is obvious, effectively reduce nt-probnp level, low incidence of adverse reactions, can improve the patient’s blood pressure and heart rate.
作者
魏斌
WEI Bin(Guangchang County People’s Hospital,Fuzhou Jiangxi 344900,China)
出处
《药品评价》
CAS
2019年第19期83-84,共2页
Drug Evaluation
基金
抚州市社会发展指导性科技计划项目(抚科计字【2018】20号序列号96)
关键词
乌拉地尔
高血压
急性心力衰竭
心功能
Uradil
High Blood Pressure
Acute Heart Failure
Cardiac Function
