摘要
目的:系统评价脐疗辅助治疗肝硬化腹水的疗效及安全性。方法:检索中国知网、维普中文科技期刊全文数据库、万方数据资源系统、中国生物医学文献数据库、PubMed、Cochrane Library数据库中脐疗治疗肝硬化腹水的随机对照文献,检索日期截至2019年2月9日。两人独立筛选文献、资料提取并核对结果,采用偏倚风险评估工具进行方法学质量评估,采用Rev Man 5.3进行疗效及安全性Meta分析。结果:共纳入13篇随机对照文献共855例患者。Meta分析显示,试验组Ⅰ/Ⅱ级腹水消退率高于对照组[RR=2.67,95%CI(1.67-4.27)];能减少腹围[WMD=-2.97,95%CI(-2.98--1.97)];降低体重[WMD=-1.68,95%CI(-2.02--1.34)];增加尿量[WMD=200.47,95%CI(147.34-253.61)],差异均有统计学意义(均P<0. 05)。对肝功能的改善效果尚不明确,不良反应较少(4.2%)。结论:脐疗辅助治疗肝硬化腹水能提高患者腹水消退率,安全性较好。
Objective:To systematically evaluate the efficacy and safety of umbilical therapy in the treatment of ascites in liver cirrhosis.Methods: The Randomized controlled trials on the treatment of cirrhotic ascites with umbilical therapy was searched in CNKI,VIP,Wanfang Data,Pub Med databases and Cochrane Library,The search date is as of February 9, 2019. The two independently screened the literature, extracted the data and checked the results, used the risk assessment tool for the methodological quality assessment, and used Rev Man 5.3 for the meta-analysis of efficacy and safety. Results:Totally 13 RCTs were included involving 855 patients. Meta-analysis showed that the grade Ⅰ-Ⅱ ascites regression rate was higher in the test group than in the control group [RR=2.67, 95% CI(1.67 to 4.27)], which reduced abdominal circumference [WMD=-2.97, 95% CI(-2.98,-1.97)], decreased body weight [WMD=-1.68, 95% CI(-2.02,-1.34)], increased urine volume [WMD=200.47, 95% CI(147.34, 253.61)], all statistically significant(P<0. 05), the improvement effect on liver function was not clear, and the adverse reactions were less(4.2%). Conclusion:Umbilical therapy for the treatment of cirrhosis ascites can improve the rate of ascites regression, and the safety is good.
作者
李婷
徐春军
李尚点
刘丹
武璇
LI Ting;XU Chun-jun;LI Shang-dian(Beijing university of traditional Chinese medicine,Beijing,100010,China;不详)
出处
《中西医结合肝病杂志》
CAS
2019年第6期533-538,共6页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
肝硬化腹水
脐疗
腹部超声
随机对照试验
系统综述
META分析
cirrhosis ascites
umbilical therapy
abdominal ultrasound
randomized controlled trial
systematic review
meta-analysis
