摘要
目的:观察加味参芪复方治疗初诊脾虚型2型糖尿病患者中医证候疗效、血糖、血脂及平均生活质量的影响。方法:将46例初诊2型糖尿病患者按1∶1随机分为治疗组和对照组,两组各23例。两组患者均采取糖尿病基础治疗包括医学营养治疗、运动治疗、戒烟等。同时治疗组予以中药加味参芪复方治疗,每日1剂,对照组予以盐酸二甲双胍片治疗,850 mg/d,两组观察疗程均为12周。观察治疗前后两组患者中医证候积分、患者生活质量评价、空腹(FPG)及餐后2 h葡萄糖(2hPBG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、甘油三酯(TG)低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等变化情况,分析加味参芪复方对初诊2型糖尿病患者的临床疗效。结果:治疗组证候疗效评价总有效率为95%,对照组为65%,治疗组优于对照组(P<0.05)。两组治疗后中医证候积分、FPG、2 hPBG及HbA1c水平均明显降低(P<0.05),其中治疗组治疗后中医证候积分明显低于对照组(P<0.05),治疗后两组FPG、2 hPBG及HbA1c水平比较无明显差异(P>0.05)。两组患者治疗后生活质量总评分较治疗前均有明显提高(P<0.05),治疗组治疗后生活质量总评分的提高明显优于对照组治疗后(P<0.05)。治疗后两组TC、TG、LDL-C、HDL-C水平明显下降(P<0.05),组间比较无明显差异(P>0.05)。结论:加味参芪复方治疗初诊脾虚型2型糖尿病患者能明显改善证候疗效,改善患者的平均生活质量以及糖脂代谢指标。
Objective:To observe the effects of Modified Shenqi Compound on TCM syndromes,blood glucose,blood lipids and average quality of life in patients with newly diagnosed type 2 diabetes mellitus with spleen deficiency.Methods:Forty-six patients with newly diagnosed type 2 diabetes were randomly divided into treatment group and control group according to 1∶1,and 23 cases in each group.The basic treatment of diabetes in both groups included medical nutrition therapy,exercise therapy and smoking cessation.At the same time,the treatment group was treated with Modified Shenqi Compound,one dose per day.The control group was treated with metformin hydrochloride tablets,850 mg/d.Both groups were observed for 12 weeks.The TCM syndrome scores,quality of life,fasting(FPG)and postprandial 2 h glucose(2 hPBG),glycated hemoglobin(HbA1 c),cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were observed before and after treatment.Then we analyzed the clinical efficacy of Modified Shenqi Compound on patients with newly diagnosed type 2 diabetes.Results:The total effective rate of the treatment group was 95%and that of the control group was 65%.The treatment group’s total effective rate was superior to that of the control group(P<0.05).The scores of TCM syndrome,FPG,2 hPBG and HbA1 c in the two groups were significantly decreased(P<0.05).The TCM syndrome scores in the treatment group were significantly lower than those in the control group(P<0.05).There was no significant difference in levels of 2 hPBG or HbA1 c(P>0.05).The total quality of life scores of the two groups were significantly increased than those before treatment(P<0.05).The improvement of the total quality of life score after treatment was significantly better than that of the control group(P<0.05).The levels of TC,TG,LDL-C and HDL-C in the two groups were significantly decreased after treatment(P<0.05)and there was no significant difference between the two groups(P>0.05).Conclusion:Modified Shenq
作者
张愿
谢红艳
周琳悦
田苑
谢春光
ZHANG Yuan;XIE Hongyan;ZHOU Linyue;TIAN Yuan;XIE Chunguang(Clinical Medical College of Chengdu University of TCM,Chengdu 6100752,Sichuan,China;The Affiliated Hospital of Chengdu University of TCM,Chengdu 610075,Sichuan,China)
出处
《中华中医药学刊》
CAS
北大核心
2019年第12期2967-2970,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81774302)
国家中医药管理局基金项目(JDZX201521)
四川省中医药管理局基金项目(2016Q022)
关键词
初诊脾虚型2型糖尿病
加味参芪复方
中医证候
生活质量
糖脂代谢
newly diagnosed type 2 diabetes with spleen deficiency
Modified Shenqi Compound
TCM syndrome
quality of life
glycolipid metabolism
