摘要
真实世界研究指选取具有代表性的受试者,根据患者的实际情况,随机选取治疗方案,进行长期观察,以评估干预的安全性和外部有效性。相对随机对照试验(RCT)而言,真实世界研究具有样本量大、受试者具有代表性、不设排除标准、疗效从患者角度评价等特点,故其所得结果更具说服力。其主要通过队列研究、横断面研究、注册登记研究、病例对照研究来实现,我国目前主要通过医院信息系统(HIS)数据库进行真实世界研究。真实世界研究在肿瘤学领域刚刚起步,目前我国肿瘤治疗仍以西医为主、中医为辅;中医方面癌症患者的证候存在差异,中医辨证治疗可作为补充治疗;此外中药注射液如复方苦参注射液在恶性肿瘤治疗中应用较多,对肿瘤患者的预后有益。
Real-world research refers to the selection of representative subjects,random selection of treatment plans based on the actual situation of patients,long-term observation to assess the safety and external effectiveness of the intervention.Relative to randomized controlled trials(RCT),real-world research has large sample sizes,representative subjects,no exclusion criteria,efficacy evaluations from a patient perspective,so the results are more convincing.It is mainly implemented through cohort studies,cross-sectional studies,registration studies,case-control studies.In China,real-world research is currently conducted mainly through the hospital information system(HIS)database.Real-world research has just started in the field of oncology.At present,China′s cancer treatment is still dominated by Western medicine and supplemented by traditional Chinese medicine.There are differences in the syndromes of cancer patients in traditional Chinese medicine.Traditional Chinese medicine syndrome differentiation treatment can be used as a supplementary treatment.In addition,traditional Chinese medicine injection such as Compound Kushen Injection is widely used in the treatment of malignant tumors,which is beneficial to the prognosis of cancer patients.
作者
王佳
杨柱
龙奉玺
伍谨林
余婷
唐东昕
WANG Jia;YANG Zhu;LONG Fengxi;WU Jinlin;YU Ting;TANG Dongxin(Graduate School,Guizhou University of Traditional Chinese Medicine,Guizhou Province,Guiyang 550000,China;Department of Science and Education,the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guizhou Province,Guiyang 550000,China;Tumor Inheritance and Scientific and Technological Innovation Talents Base of Traditional Chinese Medicine in Guizhou Province,Guizhou Province,Guiyang 550000,China)
出处
《中国医药导报》
CAS
2019年第34期46-49,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81673862、81660833、81760814)
贵州省研究生导师工作室建设项目(黔教研合GZS字[2016]08)
贵州省研究生工作站建设项目(黔教研合JYSZ字[2014]018)
贵州省高层次创新型人才培养项目(黔科合人才[2016]4032号)
贵州省人才基地建设项目(黔人领发[2018]3号)
关键词
真实世界研究
随机对照试验
恶性肿瘤
中医药
Real-world research
Randomized controlled trials
Malignant tumor
Traditional Chinese medicine
