摘要
目的:研究长链非编码RNA MT1JP在结直肠癌中的临床意义。方法:收集山东省千佛山医院和肥城矿业中心医院结直肠癌及对应癌旁组织临床标本,实时定量PCR检测结直肠癌组织中MT1JP表达量,分析MT1JP表达量与结直肠癌患者癌胚抗原(CEA)水平及临床病理特征之间的关系。结果:共收集结直肠癌及对应癌旁组织146例,MT1JP在结直肠癌组织中表达明显低于癌旁组织(P<0.01),MT1JP表达水平与患者CEA水平呈负相关(r=-0.45,P<0.01),并且MT1JP低表达与肿瘤大小(P<0.01)、浸润深度(P<0.01)、淋巴结转移(P<0.01)、远处转移(P=0.01)及TNM分期(P<0.01)相关。结论:长链非编码RNA MT1JP在结直肠癌中是一种抑癌基因,可抑制结直肠癌的临床进展,并且可能成为结直肠癌患者潜在的诊断标志物。
Objective:Investigating the clinical significance of long non-coding RNA MT1JP in colorectal cancer.Methods:The colorectal cancer tissues were collected in Shandong Provincial Qianfoshan Hospital and Feicheng Kuangye Central Hospital.Expression of MT1JP was measured by quantitative PCR assay.The relationship between MT1JP expression and the clinicopathological features and CEA level of colorectal cancer patients was statistically analyzed.Results:A total of 146 colorectal cancer tissues and paired tumor adjacent tissues were collected.MT1JP was found to be downregulated in colorectal cancer tissues compared with paired tumor adjacent tissues(P<0.01).A negative correlation between the expression level of MT1JP and CEA was found(r=-0.45,P<0.01).Besides,the expression level of MT1JP was revealed to be significantly correlated with tumor size(P<0.01),tumor depth(P<0.01),lymph node invasion(P<0.01),distant metastasis(P<0.01)and TNM stage(P<0.01)of colorectal cancer.Conclusion:MT1JP may serve as a tumor suppressor in colorectal cancer,and could inhibit the clinical progression of colorectal cancer.MT1JP may be a potential diagnostic biomarker in colorectal cancer.
作者
成冬冬
刘宁
王晓
杨辉
CHENG Dong-dong;LIU Ning;WANG Xiao;YANG Hui(Department of General Surgery,Feicheng Mineral Central Hospital,Taian 271600,China;Department of Pathology,Feicheng Mineral Central Hospital,Taian 271600,China;Department of Gastroenterology Surgery,Shandong Provincial Qianfoshan Hospital,the First Affiliated Hospital of Shandong First Medical University,Jinan 250014,China)
出处
《中国现代普通外科进展》
CAS
2019年第11期841-844,共4页
Chinese Journal of Current Advances in General Surgery
