摘要
目的从theta-gamma相位幅度耦合因果脑网络角度探讨注意力缺陷/多动障碍(ADHD)儿童可能的神经电生理机制。方法22例ADHD儿童作为病例组,14例健康儿童作为对照。采集两组受试者静息态脑电,使用平均向量长度方法计算所有导联对间theta节律相位对gamma节律幅度的耦合值,分别构建两受试组的因果连接脑网络,使用非参数检验分析两受试组间的耦合差异。结果ADHD组导联内的耦合强度减弱,Fp1、Fp2导联内的耦合强度显著低于对照组(P<0.05)。两组受试者导联内的耦合强度与其作为幅度导联被其他脑区耦合的平均强度具有极强的正相关关系(对照组rs=0.863,ADHD组rs=0.787,均P<0.001)。对照组以左额区(Fp1、F3)、右枕区(O2)被其他脑区耦合为主,而ADHD组则以枕区(O1、O2)被其他脑区耦合为主。与对照组相比,ADHD组前额区(Fp1、Fp2)被其他多个脑区耦合的强度显著降低,同时还存在脑区内和脑区间耦合模式转变。结论前额区为主的多个脑区内耦合减弱,前额区被其他脑区耦合减弱,被耦合中心部分转移等因果脑网络异常,以及相位幅度耦合模式的转变可能是ADHD儿童静息态脑电特有的神经电生理特征。
Objective To investigate the possible electrophysiological mechanisms of attention deficit/hyperactivity disorder(ADHD)in children from the perspective of causal brain network of theta-gamma phase amplitude coupling.Methods A case-control study was conducted.Twenty-two children with ADHD and 14 healthy children were recruited as case group and control group,respectively.Resting electroencephalogram of the two groups were collected and the average vector length method was used to calculate the coupling value of theta rhythm phase to gamma rhythm amplitude in all paired channels.Then the causal connection brain network of the two groups was constructed.The nonparametric test was used to analyze the differences of coupling characteristics between the two groups.Results The coupling intensity within the channel of ADHD group were decreased,and the coupling intensity in Fp1 and Fp2 were significantly lower than that of the control group(P<0.05).When the channel served as the amplitude providing channel,there was a strong positive correlation between the coupling intensity within the channel and the average coupling intensity of other channels(rs=0.863 in control group,rs=0.787 in ADHD group,both P<0.001).In control group,the left frontal area(Fp1,F3)and the right occipital area(O2)were dominant coupled centers,while they were occipital region(O1,O2)in ADHD group.Compared with the control group,the coupled intensity of prefrontal lobe(Fp1,Fp2)by other brain lobes in ADHD group was significantly decreased.In addition,there were coupling pattern changes both within and between channel in ADHD group.Conclusion The causal connection brain network abnormalities such as decreasing coupling within prefrontal lobe,the prefrontal lobe weakening coupled by other brain lobes,the partial transferring of the coupled center,and the changing of the phase amplitude coupling pattern within and between brain lobes may be the specific electrophysiological characteristics of resting electroencephalogram in children with ADHD.
作者
刘兴平
孙凌
王珊珊
房蓓
王索刚
Liu Xingping;Sun Ling;Wang Shanshan;Fang Bei;Wang Suogang(School of Biomedical Engineering and Technology,Tianjin Medical University,Tianjin 300070,China;不详)
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2019年第6期490-496,共7页
Space Medicine & Medical Engineering
基金
国家自然科学基金(61175118,61977050)
国家教育部留学回国人员科研启动基金(20111568)
天津市教委科研计划项目(2018KJ083)
关键词
注意力缺陷/多动障碍
相位幅度耦合
交叉频率耦合
脑网络
静息态脑电图
attention deficit/hyperactivity disorder
phase amplitude coupling
cross-frequency coupling
brain network
resting electroencephalogram
