摘要
①目的探讨血清Clara细胞分泌蛋白(Clara cell secretion protein,CC16)用于评估腹腔镜肝胆手术患者肺脏损伤的临床价值。②方法择期腹腔镜下行胆管手术患者40例,随机分观察组和对照组:每组各20例。分别在麻醉诱导前(T0)、气腹前(T1)、气腹90分后(T2)、拔管后10分(T3)、拔管后60分(T4)抽取患者外周静脉血,检测血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白介素-6(Interleukin-6,IL-6)和CC16的水平。③结果两组患者术前一般情况比较差异无统计学意义(P>0.05);两组患者在气腹及放气后血清中MDA、TNF-α、IL-6和CC16均逐渐升高,SOD活力逐渐降低,观察组各项指标变化明显小于对照组,且差异具有统计学意义(P<0.05)。④结论外周血清CC16的变化与腹腔镜手术患者血清中氧化应激及炎症反应相关指标变化相一致,可作为临床评估氧浓度对腹腔镜手术患者肺脏影响的一种指标;术中机械通气采用较低吸入氧浓度(40%)对肺脏损伤更小。
Objective To investigate the clinical value of serum CC16 in evaluating the effects of oxygen concentration on pulmonary of patients undergoing laparoscopic biliary operation.Methods Forty patients undergoing biliary tractsurgery were randomly divided into two groups(n=20).Peripheral venous bloodsamples were drawn to detect the level of MDA,SOD,TNF-α,IL-6 and CC16 at five timepoints:before induction of anesthesia(T0),before pneumoperitoneum(T1),90 min after pneumoperitoneum(T2),10min after extubation(T3),60 min after extubation(T4).Results Compared with pre-pneumoperitoneum,the level of MDA,TNF-α,IL-6 and CC16 raised gradually,while the activity of SOD decreased(P<0.05),the differences between the two groups were signifincant,changes in observation group L were more remarkable than that in control group(P<0.05).Conclusion Level of serum CC16 is in good agreement with indicators of inflammation and oxidative stress,and it is a parameter that could be used for assessment of actue lung injury after pneumoperitoneum.
作者
胡斌
王英
罗文文
许艳荣
赵昕
宁庚
徐凯智
HU Bin;WANG Ying;LUO Wenwen(North China University of Science and Technology,Tangshan 063210,China)
出处
《华北理工大学学报（医学版）》
2020年第1期29-32,共4页
Journal of North China University of Science and Technology：Health Sciences Edition
关键词
气腹
肺损伤
氧浓度
CC16
Pneumoperitoneum
Lung injury
Oxygen concentration
CC16
