摘要
目的研究基于基因检测指导的华法林个体化用药方案在首次发生急性下肢深静脉血栓(DVT)患者抗凝治疗中的作用。方法回顾性分析2016年1月至2017年6月期间济宁医学院附属医院血管外科收治的首次确诊DVT患者62例,其中个体化组33例,经验组29例。所有患者均经彩色多普勒超声明确诊断。收集以下信息:性别、年龄、初始国际标准化比值(INR)测定结果,初次服药至INR达标的时间、增加剂量过程中是否出现INR超标。结果两组患者性别、年龄、初始INR比较差异均无统计学意义(P>0.05),个体化组达标时间明显短于经验组[(13.8±6.8)d vs(17.6±7.5)d,P<0.05];两组INR超标情况差异无统计学意义(P=0.377)。结论对于首次发生DVT患者,基于基因检测指导的华法林个体化用药方案可在不增加出血风险的前提下,缩短药物达标时间。
Objective To study the effect of warfarin individualized drug regimen based on gene detection on anticoagulation in patients with acute deep vein thrombosis(DVT).Methods From January2016 to June 2017,62 patients with DVT diagnosed for the first time in vascular surgery of the Affiliated Hospital of Jining Medical College were analyzed retrospectively,including 33 in the individualized group and 29 in the experience group.All patients were diagnosed by Color Doppler Ultrasound(CDUS).Gender,age,the results of the initial international standardized ratio(INR)measurement,the time from the first dose to the INR standard,and whether the INR exceeds the standard in the process of increasing the dose were collected.Results There was no significant difference in sex,age and initial INR between the two groups(P>0.05).The time of reaching the standard in the individualized group was significantly lower than that in the experience group[(13.8±6.8)d vs(17.6±7.5)d,P<0.05];There was no significant difference in INR between the two groups(P=0.377).Conclusions For the patients with DVT for the first time,the individualized drug regimen of warfarin based on the guidance of gene detection can shorten the time of reaching the standard without increasing the risk of bleeding.
作者
闫彬
谷涌泉
孙自强
王春梅
张成超
Yan Bin;Gu Yongquan;Sun Ziqiang;Wang Chunmei;Zhang Chengchao(Department of Vascular Surgery,Xuanwu Hospital,Institute of Vascular Surgery,Capital Medical University,Beijing 100053,China;Department of Vascular Surgery,Affiliated Hospital of Jining Medical University,Jining 272029,China)
出处
《中国医师杂志》
CAS
2019年第12期1768-1770,共3页
Journal of Chinese Physician
基金
北京市医院管理局“登峰”人才培养计划(DFL201508013)
首都卫生发展科研专项项目(首发2016-1-20124)
国家重点研发计划项目(2017YFC1104100)
北京市属医院科研培育计划(PX2018035)
北京市医管局青苗计划(QML20180804)~~
关键词
华法林
基因检测
下肢深静脉血栓
国际标准化比
Warfarin
Genetic testing
Lower extremity deep vein thrombosis
International normalized ratio
