摘要
Objective The aim of this study was to investigate the expression and clinical significance of miR-155 and miR-181 in gastric cancer.Methods Sixty-eight patients with gastric cancer and 80 healthy volunteers were selected as subjects.Serum samples of patients and volunteers were collected to detect miR-155 and miR-181 expression levels in serum and tumor tissues.Results miR-155 and miR-181 serum levels were significantly higher in patients with gastric cancer than those in the control group(P<0.05).miR-155 and miR-181 expression levels in gastric cancer tissues were 16.74±4.29 and 12.17±3.26,respectively and 3.42±0.39) and 3.06±0.69 in paracancerous tissues,respectively,and they were 1.22±0.21 and 1.08±0.35 in normal tissues,respectively.miR-155 and miR-181 expression levels in cancer tissues were significantly higher than adjacent tissues,and they were lowest in normal tissues(P<0.05).High miR-155 and miR-181 expression had significant effects on differentiation,T stage,lymph node metastasis,and clinical stage(P<0.05).Cox multivariate analysis showed that onset,T stage,clinical stage,differentiation degree,lymph node metastasis,miR-155,and miR-181 were independent risk factors for prognosis of patients with gastric cancer.Conclusion Serum miR-155 and miR-181 have a diagnostic value in gastric cancer,and they are strong signals of poor prognosis.
Objective The aim of this study was to investigate the expression and clinical significance of miR-155 and miR-181 in gastric cancer. Methods Sixty-eight patients with gastric cancer and 80 healthy volunteers were selected as subjects. Serum samples of patients and volunteers were collected to detect miR-155 and miR-181 expression levels in serum and tumor tissues. Results miR-155 and miR-181 serum levels were significantly higher in patients with gastric cancer than those in the control group(P < 0.05). miR-155 and miR-181 expression levels in gastric cancer tissues were 16.74 ± 4.29 and 12.17 ± 3.26, respectively and 3.42 ± 0.39) and 3.06 ± 0.69 in paracancerous tissues, respectively, and they were 1.22 ± 0.21 and 1.08 ± 0.35 in normal tissues, respectively. miR-155 and miR-181 expression levels in cancer tissues were significantly higher than adjacent tissues, and they were lowest in normal tissues(P < 0.05). High miR-155 and miR-181 expression had significant effects on differentiation, T stage, lymph node metastasis, and clinical stage(P < 0.05). Cox multivariate analysis showed that onset, T stage, clinical stage, differentiation degree, lymph node metastasis, miR-155, and miR-181 were independent risk factors for prognosis of patients with gastric cancer.Conclusion Serum miR-155 and miR-181 have a diagnostic value in gastric cancer, and they are strong signals of poor prognosis.
基金
Supported by a grant from the Jiangsu Provincial Health and Family Planning Commission in 2015 face project(No.H201518)
