摘要
目的:观察清金化痰汤联合多索茶碱治疗急性咳嗽的临床疗效。方法:将144例患者根据治疗方法的不同分为观察组100例与对照组44例,对照组给予多索茶碱治疗,观察组在对照组治疗的基础上给予清金化痰汤治疗2组均连续治疗7天。观察2组治疗前后临床有效率,记录临床症状消失时间,测定第1秒用力呼气量(FEV)、用力肺活量(FVC)、白细胞介素4(IL-4)和白细胞介素5(IL-5)水平。结果:总有效率观察组为99.0%,对照组为77.3%,2组比较差异有统计学意义(P<0.05)。喘息、咳嗽、湿啰音等症状消失时间观察组显著短于对照组(P<0.05)。第一秒用力呼气量(FEV1)和用力肺活量(FVC)治疗后2组均高于治疗前差异有统计学意义(P<0.05),治疗后观察组高于对照组,差异有统计学意义(P<0.05)。白细胞介素5(IL-5)、白细胞介素4(IL-4)治疗后2组均低于治疗前,差异有统计学意义(P<0.05);治疗后观察组低于对照组,差异有统计学意义(P<0.05)。结论:清金化痰汤联合多索茶碱治疗急性咳嗽能提高治疗效果,促进临床症状消失,抑制炎性反应,改善肺功能。
Objective:To survey clinical effects of Qingjin Huatan Tang combined with doxofylline in the treatment for acute cough.Methods:Altogether 144 patients were allocated to 100 cases of the observation group and 44 cases of the control group according to different therapies,the control group was treated with doxofylline,the observation group took Qingjin Huatan Tang based on the therapy the control group accepted,both groups were treated for seven days consecutively.To observe clinical effective rate before and after treating in two groups,record the disappearing time of clinical symptoms,and detect the levels of Forced expiration in the first second(FEV1),forced vital capacity(FVC),IL-4 and IL-5.Results:Total effective rate of the observation group was 99.0%,higher than 113% of the control group,and the difference could be found(P<0.05).The observation group was shorter than the control group in the disappearing time of the symptoms including panting,coughing,wet rale and others notably(P<0.05).FEVI and forced vital capacity FVC of both groups after treating were higher than these before treating,and the difference had statistical meaning(P<0.05);after treating,the observation group was higher than the control group,and the difference had statistical meaning(P<0.05).The levels of IL-5 and IL-4 in both groups after treating were lower than these before treating,and the difference was statistically significant(P <0.05);the observation group was lower than the control group after treating,and the difference could be found(P <0.05).Conclusion:Qingjin Huatan Tang combined with doxofylline in the treatment for acute cough could raise therapeutic effects,promote the disappearing of clinical symptoms,inhibit inflammatory reaction and improve pulmonary function.
作者
姚小青
褚亚红
YAO Xiaoqing;CHU Yahong(Baoji City TCM Hospital,Baoji 721000,China)
出处
《西部中医药》
2019年第10期73-75,共3页
Western Journal of Traditional Chinese Medicine
关键词
咳嗽
急性
清金化痰汤
多索茶碱
炎性反应
cough,acute
Qingjin Huatan Tang
doxofylline
inflammatory reaction
