摘要
目的检测妊娠期肝内胆汁淤积症(ICP)患者血清25-羟维生素D[25-(OH)D]水平,探讨25-(OH)D水平与ICP的相关性。方法采用高效液相色谱-串联质谱法对107例首次诊断为ICP的孕妇和60例健康对照孕妇进行血清25-(OH)D检测,采用生化酶反应法检测血清总胆汁酸水平。结果ICP孕妇25-(OH)D缺乏比例较正常孕妇显著升高;正常对照组、轻度ICP组、重度ICP组孕妇血清25-(OH)D水平分别为(23.28±9.81)、(21.59±10.66)、(18.05±8.77)ng/ml;重度、轻度ICP组25-(OH)D水平均小于正常对照组,差异均有统计学意义(t=3.532、2.570,均P<0.05);25-(OH)D与总胆汁酸水平无明显相关(r=-0.149,P>0.05)。结论重度ICP孕妇存在25-(OH)D水平较正常孕妇低的情况,与ICP的发病可能存在一定的关系。
Objective To investigate the correlation of serum 25-hydroxyvitamin D[25-(OH)D]levels with intrahepatic cholestasis of pregnancy(ICP).Methods The serum 25-(OH)D levels were detected by high performance liquid chromatography-tandem mass spectrometry in 107 ICP patients and 60 normal pregnant women.Serum total bile acid was measured by biochemical enzyme reaction method.Results The serum 25-(OH)D in severe ICP and mild ICP groups were significant lower than those of normal control group[(21.59±10.66)ng/ml,(18.05±8.77)ng/ml vs.(23.28±9.81)ng/ml,t=3.532,2.570,P<0.05].There was no significant correlation between 25-(OH)D and total bile acid levelsZ(r=-0.149,P>0.05).Conclusion The serum 25-hydroxyvitamin D levels in severe ICP patients are lower than those of normal pregnant women and mild ICP patients.
作者
王奔
黄晓钦
施晓华
朱晓燕
韩利娟
林雪峰
WANG Ben;HUANG Xiaoqin;SHI Xiaohua(Department of Laboratory,Yueqing Maternity and child Health Car hospital,yueqing 325600,china)
出处
《浙江医学》
CAS
2019年第24期2631-2633,共3页
Zhejiang Medical Journal
基金
温州市医药卫生科研项目计划（2018B38)
