摘要
目的探讨冠心病(CHD)患者外周血中性粒细胞CD99表达水平与冠心病的关系。方法选择行冠状动脉造影的患者338例,根据冠状动脉造影检查结果,冠状动脉狭窄≥50%的患者245例设为冠心病组,冠状动脉狭窄<50%的患者93例设为冠状动脉粥样硬化组(简称硬化组)。比较两组患者冠心病相关指标及外周血中性粒细胞表达CD99水平,采用多因素logistic回归分析冠心病患者各危险因素及中性粒细胞CD99表达水平与冠心病的关系。结果冠心病组中性粒细胞CD99表达水平显著高于冠状动脉粥样硬化组(P<0.01),多因素logistic回归分析结果显示,年龄、糖尿病、高血压、吸烟、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、中性粒细胞CD99表达水平与冠心病均呈正相关(P<0.05或0.01)。结论中性粒细胞CD99表达水平是冠心病的危险因素,可作为冠心病的预测指标之一。
Objective To analyze the relationship between the expression of CD99 in peripheral neutrophils and coronary heart disease(CHD).Methods Total 338 patients who underwent coronary angiography in Department of Cardiology in our hospital from July2013 to July 2014 were enrolled in the study.Among them,245 patients had coronary artery stenosis≥50%(coronary heart disease group)and 93 patients had coronary artery stenosis<50%(coronary atherosclerosis group).The related indexes of coronary heart disease and the expression of CD99 on neutrophils in peripheral blood were compared between the two groups.Correlation between the risk factors and the expression of neutrophil CD99 in patients with coronary heart disease were analyzed by multivariate logistic regression.Results The expression level of neutrophil CD99 in coronary heart disease group was significantly higher than that in coronary atherosclerosis group(P<0.01).Multivariate Logistic regression analysis showed that age,diabetes,hypertension,smoking,total cholesterol(TC),triglyceride(TC),low density lipoprotein cholesterol(LDL-C),neutrophil CD99 expression levels were positively correlated with coronary heart disease(P<0.05 or0.01).Conclusion The expression of neutrophil CD99 is a risk factor for CHD,which may be used as a predictor of CHD.
作者
林晓晓
高贝贝
黄进宇
LIN Xiaoxiao;GAO Beibei;HUANGJinyu(Department of Cardiology,Nanjing Medical University,Nanjing 211166,China)
出处
《浙江医学》
CAS
2019年第24期2603-2606,共4页
Zhejiang Medical Journal
基金
浙江省医药卫生科技项目（2016ZDB010)
