摘要
目的探讨颈动脉易损斑块与心血管事件的发生有无相关性。方法选取2016年1月至2017年4月该院收治的患者635例,记录心血管危险因素及服药史,住院期间进行颈动脉超声检查,测量颈总动脉平均内中膜厚度、狭窄指数等,依据斑块形态学分为正常组(209例)、钙化斑块组(216例)和易损斑块组(210例),出院后随访半年,采用Cox比例风险回归分析评估颈动脉斑块对心血管事件发生的预测价值,采用Kaplan-Meier方法分析无事件生存率。结果在平衡了降压药服药史、冠心病病史、血糖、平均颈总动脉内中膜厚度等因素后颈动脉斑块形态学依然对心血管事件具有很高的预测价值(危害比=13.79,95%可信区间:1.877~101.375,P=0.010)。结论颈动脉易损斑块对心血管事件的发生率预测价值高。
Objective To investigate the association between the carotid vulnerable plaque and cardiovascular outcomes.Methods We enrolled six hundred and thirty-five patients from January 2016 to April 2017,recording the cardiovascular risk factors and the history of medicine.Carotid color ultrasonography was performed when participants was hospitalization,measuring the mean intima-media thickness(IMT)of common carotid artery(CAI)and the narrowing index.Then according the plaque morphology phenotype,participants were divided into normal group,calcified plaque group and vulnerable plaque group.All patients were followed up for half a year.Cox proportional hazards regression analysis were used to assess the predictive value of carotid plaque on cardiovascular events.Kaplan-Meier method was used to evaluate the event-free survival.Results After balancing those factors,including the history of antihypertensive drugs,the coronary heart disease,the fasting blood glucose and the mean intima-media thickness of common carotid artery,the morphology phenotype of carotid plaque still has high predictive value for cardiovascular incidents(HR=13.79,95%CI:1.877-101.375,P=0.010).Conclusion Carotid vulnerable plaque has a good predictive value for cardiovascular outcomes.
作者
张会
罗涛
槐勇
ZHANG Hui;LUO Tao;HUAI Yong(Department of Cardiology,the 983th Hospital of the People′s Liberation Army Joint Service Support Force,Tianjin 300142,China)
出处
《重庆医学》
CAS
2019年第S02期38-42,共5页
Chongqing medicine
关键词
颈动脉易损斑块
预测价值
carotid vulnerable plaque
predictive value
