摘要
目的探讨分析妇科恶性肿瘤合并糖尿病患者血清糖化血红蛋白(HbAlc)、抗苗勒管激素(AMH)和视黄醇结合蛋白4(RBP4)水平与术后恢复的相关性。方法选取2017年1月至2018年1月我院收治的自愿行手术治疗的恶性肿瘤合并糖尿病患者112例为观察组,以同一时期来我院行手术治疗的无糖尿病妇科肿瘤患者108例为对照组,检测两组患者手术前后血清HbAlc、AMH和RBP4水平,比较两组患者手术时间、术中出血量、术后住院时间及不良反应发生情况,根据观察组患者术后1年内是否发生肿瘤复发,分析血清HbAlc、AMH和RBP4水平与复发的关系。结果术前及术后3月观察组HbAlc、AMH和RBP4水平均显著高于对照组,差异具有统计学意义(P<0.05);术后两组HbAlc、AMH和RBP4水平较术前均显著降低,差异具有统计学意义(P<0.05);观察组手术时间、术后住院时间以及不良反应发生率均显著高于对照组,差异具有统计学意义(P<0.05),两组术中出血量比较差异无统计学意义(P>0.05);HbAlc、AMH和RBP4水平与肿瘤复发存在相关性,二分类Logistic回归分析表明HbAlc(OR=2.682,95%CI:1.141~4.776,P=0.028)、AMH(OR=1.252,95%CI:1.021~1.291,P=0.032)和RBP4(OR=2.874,95%CI:1.438~5.257,P=0.024)是影响恶性肿瘤合并糖尿病患者术后复发的独立危险因素。结论妇科恶性肿瘤合并糖尿病患者血清HbAlc、AMH和RBP4水平显著升高,并与术后肿瘤复发相关。
Objective To investigate the correlation between serum HbAlc,AMH and RBP4 levels in patients with gynecologic malignancies and diabetes mellitus.Methods A total of 112 patients with malignant tumors and diabetes mellitus admitted to our hospital from January,2017 to January,2018 were enrolled in the observation group,while 108 patients with non-diabetic gynecologic tumors who underwent surgery in our hospital during the same period were selected as the control group.The serum HbAlc,AMH and RBP4 levels were measured before and after the surgery.The operation time,intraoperative blood loss,duration of postoperative hospital stay and adverse reactions were compared between the two groups.The relationship between serum HbAlc,AMH and RBP4 levels and recurrence was evaluated.Results The levels of HbAlc,AMH and RBP4 in the observation group were significantly higher than those in the control group before and 3 months after the operation(P<0.05).The levels of HbAlc,AMH and RBP4 after the operation in the two groups were significantly lower than those before the operation(P<0.05).The operation time,postoperative hospital stay duration and adverse reaction rate were significantly higher in the observation group than in the control group(P<0.05).The HbAlc,AMH and RBP4 levels were correlated with tumor recurrence after the operation.Logistic regression analysis showed that HbAlc(OR=2.682,95%CI:1.141-4.776,P=0.028),AMH(OR=1.252,95%CI:1.021-1.291,P=0.032)and RBP4(OR=2.874,95%CI:1.438-5.257,P=0.024)were independent risk factors for postoperative recurrence in patients with malignant tumors and diabetes.Conclusion The levels of serum HbAlc,AMH and RBP4 in gynecologic malignant tumors patients with diabetes mellitus are related to the tumor recurrence.
作者
高伟聪
李丽
张中华
朱向辉
刘素巧
GAO Wei-cong;LI Li;ZHANG Zhong-hua;ZHU Xiang-hui;LIU Su-qiao(Department of Clinical Laboratory,Second Hospital of Shijiazhuang City,Shijiazhuang 050051,China;Department of Gynecology,Second Hospital of Shijiazhuang City,Shijiazhuang 050051,China)
出处
《标记免疫分析与临床》
CAS
2019年第12期2030-2033,共4页
Labeled Immunoassays and Clinical Medicine
基金
石家庄市重点研发计划项目(编号:171461463)
关键词
妇科恶性肿瘤
糖尿病
糖化血红蛋白
抗苗勒管激素
视黄醇结合蛋白4
Gynecological malignant tumor
Diabetes
Glycated hemoglobin
Anti-Mullerian hormone
Retinol binding protein 4
