摘要
目的研究米非司酮联合米索前列醇不同给药方式行药物流产的安全性。方法选取2017年2月-2018年3月在驻马店市中心医院门诊妇产科行药物流产的妊娠妇女100例,随机分为对照组和观察组,每组各50例。对照组使用米非司酮联合口服米索前列醇,观察组采用米非司酮联合阴道给予米索前列醇。观察两组的流产成功率、胚胎排出时间、阴道出血量以及并发症发生率。结果治疗后观察组的流产成功率高于对照组,但无统计学差异(P> 0.05);观察组的胚胎排出时间及阴道出血量均低于对照组;并发症发生率也明显低于对照组,差异有统计学意义(P <0.05)。结论应用米非司酮联合阴道给予米索前列醇行妊娠终止,疗效可靠,安全性高。
Objective To study the safety of mifepristone combined with misoprostol in different ways of drug abortion. Methods From February 2017 to March 2018, 100 pregnant women were randomLy divided into two groups: control group and observation group. The control group was treated with mifepristone and misoprostol, while the observation group was treated with mifepristone and misoprostol by vagina. The success rate of abortion, the time of embryo expulsion, the amount of vaginal bleeding and the incidence of complications were observed. Results After treatment, the success rate of abortion in the observation group was higher than that in the control group, but there was no statistical difference;the time of embryo expulsion and the amount of vaginal bleeding in the observation group were lower than that in the control group;the incidence of complications was also significantly lower than that in the control group. Conclusion The combination of mifepristone and misoprostol for termination of pregnancy is effective and safe.
作者
李鸿儒
付凯
LI Hongru;FU Kai(Department of Pharmacy,Zhumadian Central Hospital,Zhumadian,Henan,463000,China)
出处
《临床研究》
2020年第1期123-124,共2页
Clinical Research
