摘要
近年来,高尿酸血症同糖尿病一样呈快速增长趋势,成为全世界重要的公共卫生问题。长期的高尿酸血症会导致急性关节炎、痛风肾等,而糖尿病因长期的慢性高血糖会造成心脏、眼睛、肾脏等的损害。目前的研究表明,高尿酸血症可通过一系列氧化应激、炎症、内皮细胞功能障碍等途径导致胰岛β细胞功能障碍、胰岛素抵抗,引起或加重糖尿病,关注两者间的本质联系有助于及早发现糖尿病高危人群,为延缓糖尿病发生发展的治疗提供一定的理论基础。
In recent years,hyperuricemia is growing rapidly,like diabetes mellitus,and has become an important public health problem in the world.Long-term hyperuricemia can lead to acute arthritis,gouty nephropathy and so on,while lasting diabetes is harmful to heart,eye and kidney and so on.Current studies show that hyperuricemia can result in isletβcell dysfunction,insulin resistance,and can cause or aggravate diabetes by oxidative stress,inflammation,endothelial cell dysfunction and other ways.Paying attention to the essential relationship between hyperuricemia and diabetes is helpful to early find out the high risk population of diabetes,and provide theoretical basis for delaying the occurrence and development of diabetes.
作者
朱丽梅
李显丽
ZHU Limei;LI Xianli(Department of Endocrinology,the Fourth Affiliated Hospital of Kunming Medical University,Kunming 650021,China)
出处
《医学综述》
2019年第22期4509-4514,共6页
Medical Recapitulate
