摘要
目的:研究九通清络膏辅治糖尿病肢体动脉闭塞症(DAO)坏死期的疗效及对患者相关功能的影响。方法:选取80例DAO坏死期患者作为研究对象,采用隐匿数字随机法分为对照组和观察组各40例,两组患者均给予基础治疗,包括降糖、抗感染等,在此基础上对照组每日以京万红软膏局部外敷,观察组每日以九通清络膏局部外敷,治疗1个月。治疗前、后检测血管内皮功能相关指标,并取创面肉芽组织行组织病理学检查,评价疗效。结果:治疗后观察组血管内皮功能等相关指标和临床疗效均优于对照组(P<0.05)。结论:九通清络膏治疗DAO可促进创面愈合,提高疗效,其作用机制可能是通过调节血管内皮功能来实现的。
Objective:To study the efficacy of Jiutong Qingluo ointment on the necrosis stage of diabetic arterial occlusion of lower extremities(DAO)and its effect on the related functions of patients.Methods:Eighty patients with the necrosis stage of DAO were selected as the research subjects and divided into a control group and an observation group with 40 cases each by a hidden number random method.All the patients were given basic treatment including hypoglycemic and antiinfection therapies and besides,the control group was topically applied with Jingwanhong ointment while the observation group with Jiutong Qingluo ointment daily for 1 month.The indicators related to endothelial function were determined before and after treatment and the pathologic examination of granulation tissue was also performed to evaluate the curative effect.Results:The endothelial function and the curative effect were better in the observation group than the control group(P<0.05).Conclusion:Jiutong Qingluo ointment for the treatment of DAO can promote wound healing and improve curative effect,and its mechanism may be realized by regulating endothelial function.
作者
相胜敏
施海燕
赵诚
曹烨民
XIANG Shengmin;SHI Haiyan;ZHAO Cheng;CAO Yemin(Department of Vascular Anomalies,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of TCM,Shanghai 200082,China;Department of General Medicine,Yinhang Community Health Service Center of Yangpu District,Shanghai 200438,China;Shanghai TCM and Western Medicine Integrated Institute of Vascular Anomalies,Shanghai 200082,China)
出处
《上海医药》
CAS
2019年第23期41-43,52,共4页
Shanghai Medical & Pharmaceutical Journal
基金
上海市进一步加快中医药事业发展三年行动计划项目(ZY(2018-2020)-CCCX-4005)
上海市科委中医引导类项目(18401903600)
上海市卫计委科研面上项目(201740093)
国家中医药传承与创新“百千万人才工程”(岐黄工程)——第六批全国老中医药专家学术继承项目(2017-29)
上海市虹口区“国医强优”三年行动计划项目(HGY-MGB-2018-01-02)
关键词
九通清络膏
糖尿病肢体动脉闭塞症
临床疗效
Jiutong Qingluo ointment
diabetic arterial occlusion of lower extremities
curative effect
