摘要
目的探讨血清肿瘤标记物异柠檬酸脱氢酶1(IDH1)对肺癌辅助诊断的临床价值。方法收集一般资料,应用酶联免疫法检测肺癌患者、非肺癌人群血清中IDH1的浓度水平,并分析其在肺癌诊断中的临床意义。结果肺癌患者血清中IDH1的浓度水平明显高于非肺癌人群[(7.12±6.98)ng/ml比(2.09±1.83)ng/ml,t=11.540,P<0.001];血清IDH1在腺癌和鳞癌中的浓度水平显著高于小细胞肺癌[(7.91±7.26)ng/ml比(2.76±2.27)ng/ml,t=6.345,P<0.001];血清IDH1在肺癌、Ⅰ+Ⅱ期肺癌、Ⅲ+Ⅳ期肺癌中检测的敏感度分别为47.4%、49.1%和46.3%。结论血清IDH1的检测对于非小细胞肺癌(鳞癌和腺癌)和小细胞肺癌的诊断、鉴别诊断以及对Ⅰ和Ⅱ期肺癌的辅助诊断具有较高的敏感度和特异性,血液IDH1在肺癌的辅助诊断中具有良好的临床应用价值。
Objective To investigate the clinical value of serum tumor marker isocitrate dehydrogenase 1(IDH1)in the diagnosis of lung cancer.Methods The general data were collected in lung cancer patients and non-lung cancer patients.The serum level of IDH1 was detected by enzyme-linked immunosorbent assay to evaluate its clinical significance in diagnosing lung cancer.Results The serum IDH1 level was significantly higher in lung cancer patients than in non-lung cancer patients[(7.12±6.98)ng/ml vs.(2.09±1.83)ng/ml,t=11.540,P<0.001].The serum IDH1 level in patients with adenocarcinoma or squamous cell carcinoma was significantly higher than that in patients with small cell lung cancer[(7.91±7.26)ng/ml vs.(2.76±2.27)ng/ml,t=6.345,P<0.001].The sensitivity of IDH1 in detecting lung cancer,stageⅠ/Ⅱlung cancer,and stageⅢ/Ⅳlung cancer was 47.4%,49.1%,and 46.3%,respectively.Conclusions Serum IDH1 has high sensitivities and specificities in the diagnosis and differential diagnosis of non-small cell lung cancer(squamous cell carcinoma and adenocarcinoma)and small cell lung cancer as well as the auxiliary diagnosis of stageⅠandⅡlung cancer.It is a valuable marker for the auxiliary diagnosis of lung cancer.
作者
谢昊
孔祥溢
张强
XIE Hao;KONG Xiangyi;ZHANG Qiang(Department of Thoracic Surgery,Jishuitan Hospital,Beijing 100035,China;Department of Breast Surgical Oncology,National Cancer Center/National Clinical Research Center for Cancer,Cancer Hospital,CAMS and PUMC,Beijing 100021,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2019年第6期813-817,共5页
Acta Academiae Medicinae Sinicae
关键词
肺癌
异柠檬酸脱氢酶1
辅助诊断
lung cancer
isocitrate dehydrogenase 1
auxiliary diagnosis
