摘要
酒精性肝病(ALD)是长期大量饮酒所导致的一系列慢性非传染性肝脏疾病。乙醇代谢过程中会产生活性氧(ROS),若ROS无法被彻底清除,所造成的氧化应激导致Kupffer细胞炎症反应和脂质过氧化,加速酒精性肝炎和纤维化的进展。人体可以表达多种酶或抗氧化物质清除ROS及其副产物以抵抗氧化应激,主要对ALD中参与抗氧化的几种酶或抗氧化物质进行了综述。
Alcoholic liver disease(ALD)is a series of chronic non-infectious liver diseases caused by long-term heavy alcohol consumption.Reactive oxygen species(ROS)is produced during alcohol metabolism,and if it is not eliminated completely,it may cause oxidative stress,which will further lead to inflammatory response of Kupffer cells and lipid peroxidation and thus accelerate the progression of alcoholic hepatitis and fibrosis.The human body can generate a variety of enzymes or antioxidants to eliminate ROS and its by-products and resist oxidative stress.This article reviews several enzymes or antioxidants involved in antioxidant activity in ALD.
作者
陈海震
黄晶
CHEN Haizhen;HUANG Jing(Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun 130021, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第12期2817-2819,共3页
Journal of Clinical Hepatology
关键词
肝疾病
酒精性
抗氧化剂
活性氧
liver diseases,alcoholic
antioxidants
reactive oxygen species
