摘要
临床多重耐药及泛耐药革兰阴性细菌的流行给抗感染治疗带来了巨大的挑战。由于新型抗菌药物研究开发缓慢,多粘菌素被老药新用作为治疗此类细菌感染的最后一道防线。该文就多粘菌素的相关药理学特性、药动学/药效学、临床研究与应用进行全面介绍,对存在的问题进行分析,对需要进一步研究内容也进行了说明。
The spread of multidrug-resistant or pandrug-resistant gram-negative bacteria.Because of the slow development of new antibiotics,polymyxins are increasingly used as a last option for such infections.Therefore,this paper reviews the latest progress in the the pharmacological properties,pharmacokinetics/pharmacodynamics,toxicity and clinical application of polymyxins to provide references the challenges for its optimal use.
作者
黄晨
肖永红
HUANG Chen;XIAO Yonghong(Department of Respiratory Medicine,Lihuili Hospital,Ningbo Medical Center,Ningbo 315000,China;State Key Laboratory for Diagnosis and Treatment of Infectious Disease,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China)
出处
《医药导报》
CAS
北大核心
2020年第1期10-16,共7页
Herald of Medicine
关键词
多粘菌素
临床应用
药理作用
Polymyxins
Clinical application
Pharmacological effects
